Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 5/20 | 0.49 |
| ▸ | HSP90AB1 | P08238 | 5/20 | 0.49 |
| ▸ | HPGD | P15428 | 8/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MLYCD | O95822 | 2/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.43 |
| ▸ | ELANE | P08246 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6439629 | 0.89 | HPGD (0.54) | HSP90AA1HSP90AB1HPGDTDP1ALDH1A1 | |
| SCHEMBL4021525 | 0.83 | HPGD (0.41) | HSP90AA1HPGDTDP1ALDH1A1CYP1A2 | |
| SCHEMBL2952990 | 0.80 | HSP90AA1 (0.57) | HSP90AA1HSP90AB1HPGDTDP1ALDH1A1 | |
| SCHEMBL31621299 | 0.80 | HSP90AA1 (0.57) | HSP90AA1HSP90AB1HPGDTDP1ALDH1A1 | |
| SCHEMBL6777079 | 0.80 | HPGD (0.54) | HSP90AA1HSP90AB1HPGDTDP1ALDH1A1 | |
| SCHEMBL13974083 | 0.80 | PGR (0.42) | HPGDTDP1ALDH1A1CYP1A2MAPT | |
| SCHEMBL4027372 | 0.79 | PDK1 (0.39) | HPGDALDH1A1CYP1A2TSHRMAPK1 | |
| SCHEMBL9853906 | 0.78 | MAPK1 (0.39) | HSP90AA1HPGDTDP1ALDH1A1CYP1A2 | |
| SCHEMBL5924442 | 0.78 | HSP90AA1 (0.63) | HSP90AA1HSP90AB1HPGDTDP1ALDH1A1 | |
| SCHEMBL11699200 | 0.78 | HPGD (0.66) | HSP90AA1HSP90AB1HPGDTDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537075-B1 | DIARYLUREA DERIVATIVES AND THEIR USE AS CHLORIDE CHANNEL BLOCKERS | NEUROSEARCH AS (DK) | 2009-07-01 | — | — | EP | disclosed |
| US-20060160856-A1 | Diarylurea derivatives and their use as chloride channel blockers | NEUROSEARCH A/S (DK) | 2006-07-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060160856-A1 | Diarylurea derivatives and their use as chloride channel blockers | KIT, ORAI1, CACNA1C | HSP90AA1 3909/4885HSP90AB1 3050/4885HPGD 1108/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.