Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 9/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.32 |
| ▸ | CCNC | P24863 | 1/20 | 0.32 |
| ▸ | CDK8 | P49336 | 1/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.31 |
| ▸ | CTSS | P25774 | 1/20 | 0.31 |
| ▸ | RORC | P51449 | 3/20 | 0.31 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4030735 | 0.89 | NPY5R (0.35) | KCNH2CYP2D6HRH1OPRL1MCHR1 | |
| SCHEMBL4024067 | 0.89 | NPY5R (0.35) | KCNH2CYP2D6HRH1OPRL1MCHR1 | |
| SCHEMBL4029262 | 0.89 | NPY5R (0.35) | KCNH2CYP2D6HRH1OPRL1MCHR1 | |
| SCHEMBL4024429 | 0.86 | OPRL1 (0.35) | LTA4HKCNH2OPRL1 | |
| SCHEMBL4028478 | 0.84 | KDM5A (0.35) | OPRL1 | |
| SCHEMBL4031855 | 0.83 | KDM5A (0.34) | OPRL1 | |
| SCHEMBL4025157 | 0.83 | KDM5A (0.34) | OPRL1 | |
| SCHEMBL4023855 | 0.83 | KDM5A (0.34) | OPRL1 | |
| SCHEMBL4024126 | 0.83 | LTA4H (0.34) | LTA4HKCNH2CYP2D6MCHR1RORC | |
| SCHEMBL4022622 | 0.83 | LTA4H (0.34) | LTA4HKCNH2CYP2D6MCHR1RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029579-A2 | CYCLOHEXYLPYRAZOLE-LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2009-03-04 | — | — | EP | disclosed |
| WO-2007124254-A2 | CYCLOHEXYLPYRAZOLE-LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2007-11-01 | — | — | WO | disclosed |