Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY5R | Q15761 | 5/20 | 0.35 |
| ▸ | CTSS | P25774 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.31 |
| ▸ | RORC | P51449 | 2/20 | 0.30 |
| ▸ | KDM5A | P29375 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4024067 | 1.00 | NPY5R (0.35) | NPY5RCTSSCYP2D6HRH1MCHR1 | |
| SCHEMBL4030735 | 1.00 | NPY5R (0.35) | NPY5RCTSSCYP2D6HRH1MCHR1 | |
| SCHEMBL4024489 | 0.90 | NPY5R (0.35) | NPY5RCTSSCYP2D6HRH1MCHR1 | |
| SCHEMBL4024182 | 0.89 | LTA4H (0.34) | CTSSCYP2D6HRH1MCHR1OPRL1 | |
| SCHEMBL4031855 | 0.85 | KDM5A (0.34) | OPRL1KDM5A | |
| SCHEMBL4023855 | 0.85 | KDM5A (0.34) | OPRL1KDM5A | |
| SCHEMBL4025157 | 0.85 | KDM5A (0.34) | OPRL1KDM5A | |
| SCHEMBL4029463 | 0.84 | SPR (0.38) | KDM5A | |
| SCHEMBL4024429 | 0.83 | OPRL1 (0.35) | HTR2AHTR2COPRL1KDM5AKCNH2 | |
| SCHEMBL4029972 | 0.82 | DDR1 (0.33) | OPRL1RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029579-A2 | CYCLOHEXYLPYRAZOLE-LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2009-03-04 | — | — | EP | disclosed |
| WO-2007124254-A2 | CYCLOHEXYLPYRAZOLE-LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2007-11-01 | — | — | WO | disclosed |