Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 7/20 | 0.46 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 2/20 | 0.41 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.40 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.39 |
| ▸ | UGCG | Q16739 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | S100A4 | P26447 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.37 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4033749 | 0.96 | PARP1 (0.47) | PARP1GRM2ACHEPARP2NR1I2 | |
| SCHEMBL24469503 | 0.94 | PARP1 (0.49) | PARP1GRM2ACHEPARP2NR1I2 | |
| SCHEMBL4033048 | 0.89 | PARP1 (0.46) | PARP1GRM2ACHEPARP2NR1I2 | |
| SCHEMBL4026219 | 0.79 | PARP1 (0.53) | PARP1PARP2NR1I2UGCGALDH1A1 | |
| SCHEMBL15729776 | 0.79 | PARP1 (0.53) | PARP1PARP2NR1I2UGCGALDH1A1 | |
| SCHEMBL4356858 | 0.79 | PARP1 (0.50) | PARP1PARP2NR1I2UGCGALDH1A1 | |
| SCHEMBL14373871 | 0.78 | PARP1 (0.60) | PARP1ACHEPARP2ALDH1A1MAPT | |
| SCHEMBL27752223 | 0.78 | KMT2A (0.38) | PARP1GRM2PARP2NR1I2UGCG | |
| SCHEMBL29695767 | 0.76 | ACHE (0.44) | PARP1ACHEPARP2ALDH1A1MAPT | |
| SCHEMBL4029942 | 0.76 | LMNA (0.56) | PARP1ACHEPARP2ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101495450-A | Isoindole derivatives useful for treating pain, gastrointestinal diseases and cancer | ASTRAZENECA AB (SE) | 2009-07-29 | — | — | CN | disclosed |
| EP-2029535-A1 | ISOINDOLE DERIVATIVES USEFUL FOR TREATING PAIN, GASTROINTESTINAL DISEASES AND CANCER | AstraZeneca AB (SE) | 2009-03-04 | — | — | EP | disclosed |
| WO-2007139464-A1 | ISOINDOLE DERIVATIVES USEFUL FOR TREATING PAIN, GASTROINTESTINAL DISEASES AND CANCER | ASTRAZENECA AB (SE) | 2007-12-06 | — | — | WO | disclosed |
| WO-2007139464-A1 | ISOINDOLE DERIVATIVES USEFUL FOR TREATING PAIN, GASTROINTESTINAL DISEASES AND CANCER | ASTRAZENECA AB (SE) | 2007-12-06 | — | — | WO | disclosed |