Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 20/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7136590 | 0.87 | CCR5 (0.55) | CCR5 | |
| SCHEMBL13677240 | 0.86 | CCR5 (0.62) | CCR5 | |
| SCHEMBL13676967 | 0.83 | CCR5 (0.62) | CCR5 | |
| SCHEMBL8444887 | 0.82 | NR1D1 (0.50) | CCR5 | |
| SCHEMBL4265056 | 0.81 | ALDH1A1 (0.55) | — | |
| SCHEMBL4020101 | 0.80 | CCR5 (0.56) | CCR5 | |
| SCHEMBL3250498 | 0.79 | CCR5 (0.51) | CCR5 | |
| Hydrochloric Acid SCHEMBL5762872 | 0.79 | CCR5 (0.55) | CCR5 | |
| SCHEMBL5724167 | 0.78 | ALDH1A1 (0.67) | — | |
| SCHEMBL7665218 | 0.78 | CCR5 (0.68) | CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009092293-A1 | PYROLLIDINE-BASED COMPOUNDS | SHANGHAI TARGETDRUG CO., LTD. (CN) | 2009-07-30 | — | — | WO | disclosed |
| WO-2009092293-A1 | PYROLLIDINE-BASED COMPOUNDS | SHANGHAI TARGETDRUG CO., LTD. (CN) | 2009-07-30 | — | — | WO | disclosed |
| WO-2009089659-A1 | PYROLLIDINE-BASED COMPOUNDS | SHANGHAI TARGETDRUG CO., LTD. (CN) | 2009-07-23 | — | — | WO | disclosed |
| US-6506777-B1 | Method for modulation of CCR-3 or CCR-5 chemokine receptor activity in a mammal in need thereof to treat asthma, allergic rhinitis, dermatitis, conjunctivitis, atherosclerosis or rheumatoid arthritis, which comprises the administration of an | MERCK & CO., INC. | 2003-01-14 | — | — | US | disclosed |
| US-6500844-B1 | PIPERIDINYL-1-METHYLCYCLOPENTANES AND STEREOISOMERS, USED AS ANTIINFLAMMATORY AND PROPHYLACTIC AGENTS AGAINST ALLERGIC RHINITIS, DERMATITIS, VISION DEFECTS, ASTHMA, ATHRITIS AND FOR PREVENTION OR DELAY OF AQUIRED IMMUNE DIFICIENCY SYNDROME | MERCK & CO., INC. | 2002-12-31 | — | — | US | disclosed |
| US-6476054-B1 | Cyclic amine modulators of chemokine receptor activity | MERCK & CO., INC. | 2002-11-05 | — | — | US | disclosed |
| US-6472410-B1 | N-cyclopentyl modulators of chemokine receptor activity | MERCK & CO., INC. | 2002-10-29 | — | — | US | disclosed |
| WO-2000076512-A1 | CYCLOPENTYL MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | MERCK & CO., INC. (US) | 2000-12-21 | — | — | WO | disclosed |
| US-6140349-A | FOR PROPHYLAXIS AND THERAPY OF HUMAN IMMUNODEFICIENCY VIRUS(HIV) INFECTIONS AND ACQUIRED IMMUNODEDICIENCY SYNDROME | MERCK & CO., INC. (US) | 2000-10-31 | — | — | US | disclosed |