Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MT-CO2 | P00403 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4902804 | 0.83 | MT-CO2 (0.50) | MT-CO2GAASMN1; SMN2MEN1KMT2A | |
| SCHEMBL6583074 | 0.82 | POLB (0.56) | MT-CO2GAASMN1; SMN2MEN1KMT2A | |
| SCHEMBL17223076 | 0.69 | CYP2A6 (0.57) | GAASMN1; SMN2MEN1KMT2AMAPT | |
| SCHEMBL5225774 | 0.68 | HTR2C (0.37) | MT-CO2GAAMEN1KMT2AMAPT | |
| SCHEMBL9275585 | 0.67 | MT-CO2 (0.70) | MT-CO2SMN1; SMN2MEN1KMT2APOLB | |
| SCHEMBL31696451 | 0.66 | SMARCA2 (0.41) | MT-CO2GAASMN1; SMN2MEN1KMT2A | |
| SCHEMBL2033213 | 0.66 | MT-CO2 (0.69) | MT-CO2GAASMN1; SMN2MEN1KMT2A | |
| SCHEMBL1692082 | 0.65 | — | — | |
| SCHEMBL7866531 | 0.65 | — | — | |
| SCHEMBL16784518 | 0.64 | MEN1 (0.73) | MT-CO2GAASMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009103022-A1 | DERIVATIVES OF SUBSTITUTED FUSED RING CYCLOINDOLES AND METHODS OF THEIR USE | ITHERX PHARMACEUTICALS, INC. (US) | 2009-08-20 | — | — | WO | disclosed |
| WO-2009103022-A1 | DERIVATIVES OF SUBSTITUTED FUSED RING CYCLOINDOLES AND METHODS OF THEIR USE | ITHERX PHARMACEUTICALS, INC. (US) | 2009-08-20 | — | — | WO | disclosed |