Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | CTSD | P07339 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2033213 | 0.83 | MT-CO2 (0.69) | POLBSMN1; SMN2GAAMT-CO2ALDH1A1 | |
| SCHEMBL4024685 | 0.82 | MT-CO2 (0.50) | POLBSMN1; SMN2GAAMT-CO2ALDH1A1 | |
| SCHEMBL4902804 | 0.82 | MT-CO2 (0.50) | POLBSMN1; SMN2GAAMT-CO2ALDH1A1 | |
| SCHEMBL8562063 | 0.71 | ALDH1A1 (0.41) | SMN1; SMN2GAAALDH1A1CTSDTDP1 | |
| SCHEMBL9466522 | 0.71 | POLB (0.53) | POLBSMN1; SMN2GAAMT-CO2MEN1 | |
| SCHEMBL9544841 | 0.71 | POLB (1.00) | POLBSMN1; SMN2GAAMT-CO2ALDH1A1 | |
| SCHEMBL10811051 | 0.71 | MT-CO2 (0.58) | POLBSMN1; SMN2MT-CO2ALDH1A1TDP1 | |
| Hydrochloric Acid SCHEMBL8321900 | 0.69 | ALDH1A1 (0.48) | GAAALDH1A1CTSDTDP1MAPT | |
| SCHEMBL5277549 | 0.69 | POLB (0.50) | POLBSMN1; SMN2GAAMT-CO2ALDH1A1 | |
| SCHEMBL5277543 | 0.69 | POLB (0.50) | POLBSMN1; SMN2GAAMT-CO2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1424337-A1 | 4-hydroxy derivatives of 5,6,9,10-tetrahydro-10-((2-methyl-1h-imidazol-1-yl)methyl)-4h-pyrido-(3,2,1-jk)-carbazol-11(8h)-one | Solvay Pharmaceuticals GmbH (DE) | 2004-06-02 | — | — | EP | disclosed |