Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | PKM | P14618 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.46 |
| ▸ | BRD4 | O60885 | 2/20 | 0.36 |
| ▸ | CA12 | O43570 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | CA9 | Q16790 | 2/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | PKLR | P30613 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | MMP3 | P08254 | 1/20 | 0.32 |
| ▸ | MMP8 | P22894 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4024965 | 1.00 | MAPT (0.47) | MAPTKMT2APKMNPC1RAB9A | |
| SCHEMBL20323029 | 0.89 | MAPT (0.41) | MAPTKMT2APKMNPC1RAB9A | |
| SCHEMBL1131569 | 0.89 | MAPT (0.41) | MAPTKMT2APKMNPC1RAB9A | |
| SCHEMBL1131570 | 0.89 | MAPT (0.41) | MAPTKMT2APKMNPC1RAB9A | |
| Hydrochloric Acid SCHEMBL338804 | 0.88 | MAPT (0.40) | MAPTKMT2APKMNPC1RAB9A | |
| Iodide SCHEMBL18063119 | 0.88 | MAPT (0.40) | MAPTKMT2APKMNPC1RAB9A | |
| Hydrochloric Acid SCHEMBL338803 | 0.88 | MAPT (0.40) | MAPTKMT2APKMNPC1RAB9A | |
| Iodide SCHEMBL18063120 | 0.88 | MAPT (0.40) | MAPTKMT2APKMNPC1RAB9A | |
| Perchlorate SCHEMBL5860332 | 0.87 | MAPT (0.41) | MAPTKMT2APKMNPC1RAB9A | |
| SCHEMBL6308287 | 0.87 | MAPT (0.41) | MAPTKMT2APKMNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7488354-B2 | Dyeing composition comprising at least one disulphide dye and method of dyeing human keratin fibers using this dye | L'OREAL S.A. (FR) | 2009-02-10 | — | — | US | disclosed |
| US-20060080791-A1 | Dyeing composition comprising at least one disulphide dye and method of dyeing human keratin fibers using this dye | L'OREAL S.A. (FR) | 2006-04-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060080791-A1 | Dyeing composition comprising at least one disulphide dye and method of dyeing human keratin fibers using this dye | KRT18, DSG1, DSC1 | MAPT 1075/4885KMT2A 1994/4885PKM 2329/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.