Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 8/20 | 0.40 |
| ▸ | RAB9A | P51151 | 6/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL338803 | 1.00 | MAPT (0.40) | MAPTRAB9AMAPK1NPC1MEN1 | |
| SCHEMBL1131569 | 0.98 | MAPT (0.41) | MAPTRAB9AMAPK1NPC1MEN1 | |
| SCHEMBL20323029 | 0.98 | MAPT (0.41) | MAPTRAB9AMAPK1NPC1MEN1 | |
| SCHEMBL1131570 | 0.98 | MAPT (0.41) | MAPTRAB9AMAPK1NPC1MEN1 | |
| Iodide SCHEMBL18063119 | 0.97 | MAPT (0.40) | MAPTRAB9AMAPK1NPC1MEN1 | |
| Iodide SCHEMBL18063120 | 0.97 | MAPT (0.40) | MAPTRAB9AMAPK1NPC1MEN1 | |
| Perchlorate SCHEMBL5860330 | 0.93 | MAPT (0.41) | MAPTRAB9AMAPK1NPC1MEN1 | |
| SCHEMBL6308285 | 0.93 | MAPT (0.41) | MAPTRAB9AMAPK1NPC1MEN1 | |
| SCHEMBL6308287 | 0.93 | MAPT (0.41) | MAPTRAB9AMAPK1NPC1MEN1 | |
| Perchlorate SCHEMBL5860332 | 0.93 | MAPT (0.41) | MAPTRAB9AMAPK1NPC1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3271423-B1 | CATIONIC DIRECT DYES | BASF SE (DE) | 2022-08-31 | — | — | EP | disclosed |
| US-20180244924-A1 | Cationic Direct Dyes | BASF SE (DE) | 2018-08-30 | — | — | US | disclosed |
| EP-3271423-A1 | CATIONIC DIRECT DYES | BASF SE (DE) | 2018-01-24 | — | — | EP | disclosed |
| WO-2016146813-A1 | CATIONIC DIRECT DYES | BASF SE (DE) | 2016-09-22 | — | — | WO | disclosed |
| US-8097044-B2 | Hair compositions comprising at least one disulfide direct dye and at least one alkaline hydroxide agent and simultaneous hair shaping and dyeing processes | L'OREAL S.A. (FR) | 2012-01-17 | — | — | US | disclosed |
| EP-2044158-B1 | POLYMERIC HAIR DYES | BASF SE (DE) | 2011-11-23 | — | — | EP | disclosed |
| EP-2259766-A2 | COMPOSITION FOR DYEING KERATIN FIBRES COMPRISING AT LEAST ONE DIRECT DYE COMPRISING A DISULPHIDE/PROTECTED-THIOL FUNCTION AND AT LEAST ONE SILICEOUS COMPOUND COMPRISING A THIOL FUNCTION AND METHOD USING THE COMPOSITION | L'Oréal (FR) | 2010-12-15 | — | — | EP | disclosed |
| US-7731761-B2 | Polymeric hair dyes | CIBA CORPORATION (US) | 2010-06-08 | — | — | US | disclosed |
| US-20090255063-A1 | Polymeric hair dyes | CIBA CORP. | 2009-10-15 | — | — | US | disclosed |
| WO-2009109457-A2 | COMPOSITION FOR DYEING KERATIN FIBRES COMPRISING AT LEAST ONE DIRECT DYE COMPRISING A DISULPHIDE/PROTECTED-THIOL FUNCTION AND AT LEAST ONE SILICEOUS COMPOUND COMPRISING A THIOL FUNCTION AND METHOD USING THE COMPOSITION | L'OREAL (FR) | 2009-09-11 | — | — | WO | disclosed |
| US-7582122-B2 | Mixed cationic dyes comprising at least one anthraquinone chromophore and their use in methods of hair dyeing | L'OREAL S.A. (FR) | 2009-09-01 | — | — | US | disclosed |
| EP-2082728-A2 | Use of cationic polymeric hair dye | Beiersdorf AG (DE) | 2009-07-29 | — | — | EP | disclosed |
| US-20090126755-A1 | Hair compositions comprising at least one disulfide direct dye and at least one alkaline hydroxide agent and simultaneous hair shaping an dyeing processes | L'OREAL S.A. (FR) | 2009-05-21 | — | — | US | disclosed |
| EP-2044158-A1 | POLYMERIC HAIR DYES | Ciba Holding Inc. (CH) | 2009-04-08 | — | — | EP | disclosed |
| US-7488354-B2 | Dyeing composition comprising at least one disulphide dye and method of dyeing human keratin fibers using this dye | L'OREAL S.A. (FR) | 2009-02-10 | — | — | US | disclosed |
| WO-2008009579-A1 | POLYMERIC HAIR DYES | CIBA HOLDING INC. (CH) | 2008-01-24 | — | — | WO | disclosed |
| US-7282068-B2 | Polycationic azo compounds for dyeing keratin fibers, dye composition containing the same, and methods for making such compounds | L'OREAL S.A. (FR) | 2007-10-16 | — | — | US | disclosed |
| US-20070125261-A1 | Mixed cationic dyes comprising at least one anthraquinone chromophore and their use in methods of hair dyeing | L'OREAL S.A. (FR) | 2007-06-07 | — | — | US | disclosed |
| US-20060080791-A1 | Dyeing composition comprising at least one disulphide dye and method of dyeing human keratin fibers using this dye | L'OREAL S.A. (FR) | 2006-04-20 | — | — | US | disclosed |
| US-20060021160-A1 | Polycationic azo compounds for dyeing keratin fibers, dye compositions containing the same, and methods for making such compounds | L'OREAL | 2006-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090126755-A1 | Hair compositions comprising at least one disulfide direct dye and at least one alkaline hydroxide agent and simultaneous hair shaping an dyeing processes | KRT18, DSG1, ALPG | ACHE 1410/4885MAPT 960/4885RAB9A 4038/4885 |
| US-20060080791-A1 | Dyeing composition comprising at least one disulphide dye and method of dyeing human keratin fibers using this dye | KRT18, DSG1, DSC1 | ACHE 4075/4885MAPT 1075/4885RAB9A 4066/4885 |
| US-20060021160-A1 | Polycationic azo compounds for dyeing keratin fibers, dye compositions containing the same, and methods for making such compounds | KRT18, CYBA, JUP | ACHE 4124/4885MAPT 1664/4885RAB9A 4619/4885 |
| US-20180244924-A1 | Cationic Direct Dyes | H1-0, TPH1, H1-2 | ACHE 2316/4885MAPT 3520/4885RAB9A 3559/4885 |
| US-20090255063-A1 | Polymeric hair dyes | SCO2, CYB5R3, OR10J3 | ACHE 4319/4885MAPT 3761/4885RAB9A 4419/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.