Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 3/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 2/20 | 0.33 |
| ▸ | HTR2C | P28335 | 2/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4019022 | 0.94 | KIF11 (0.37) | KIF11ACHEP2RX7HRH3ALDH1A1 | |
| SCHEMBL4025183 | 0.94 | KIF11 (0.37) | KIF11ACHEP2RX7HRH3ALDH1A1 | |
| SCHEMBL4027189 | 0.89 | KCNH2 (0.35) | KIF11KCNH2HTR2AHTR2CALDH1A1 | |
| SCHEMBL4020571 | 0.89 | KCNH2 (0.35) | KIF11KCNH2HTR2AHTR2CALDH1A1 | |
| SCHEMBL4028852 | 0.88 | KCNH2 (0.37) | KIF11KCNH2HTR2AHTR2CSLC6A4 | |
| SCHEMBL4026061 | 0.88 | KIF11 (0.43) | KIF11KCNH2HTR2AHTR2CALDH1A1 | |
| SCHEMBL4027448 | 0.87 | KDM2B (0.37) | KIF11KCNH2ALDH1A1LMNAKMT2A | |
| SCHEMBL4024600 | 0.87 | L3MBTL1 (0.34) | KIF11KCNH2HTR2AALDH1A1KMT2A | |
| SCHEMBL4026679 | 0.87 | L3MBTL1 (0.34) | KIF11KCNH2HTR2AALDH1A1KMT2A | |
| SCHEMBL4778087 | 0.86 | KIF11 (0.47) | KIF11ACHEGRIN2BP2RX7HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7572814-B2 | 3,5-dibenzoyl-4-phenyl-piperidine anti-cancer compounds | CYTOKINETICS, INCORPORATED (US) | 2009-08-11 | — | — | US | disclosed |
| US-20070161674-A1 | Certain chemical entities, compositions, and methods | CYTOKINETICS, INC. | 2007-07-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070161674-A1 | Certain chemical entities, compositions, and methods | TP53, VHL, RB1 | KIF11 3745/4885ACHE 2619/4885GRIN2B 4170/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.