Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.62 |
| ▸ | LMNA | P02545 | 3/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.53 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 2/20 | 0.43 |
| ▸ | BAZ2B | Q9UIF8 | 2/20 | 0.42 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.42 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.42 |
| ▸ | CDK1 | P06493 | 1/20 | 0.42 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.42 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1612144 | 0.97 | HSD17B10 (0.64) | MAPTLMNAHSD17B10ALDH1A1MAPK1 | |
| SCHEMBL1004766 | 0.88 | MAPT (0.50) | MAPTLMNAHSD17B10ALDH1A1MAPK1 | |
| SCHEMBL2303878 | 0.81 | ALDH1A1 (0.60) | MAPTLMNAHSD17B10ALDH1A1MAPK1 | |
| SCHEMBL6921570 | 0.81 | DYRK1A (0.46) | LMNAALDH1A1DYRK1AHPGDKDR | |
| SCHEMBL2301312 | 0.81 | LMNA (0.60) | LMNAHSD17B10ALDH1A1MAPK1MAP3K14 | |
| SCHEMBL10154866 | 0.81 | KDR (0.66) | MAPTLMNAHSD17B10ALDH1A1MAPK1 | |
| SCHEMBL6925320 | 0.78 | KDR (0.70) | MAPTLMNAHSD17B10ALDH1A1PARP1 | |
| SCHEMBL13746901 | 0.78 | MAPT (0.57) | MAPTLMNAHSD17B10ALDH1A1MAPK1 | |
| SCHEMBL22128354 | 0.78 | HSD17B10 (0.44) | MAPTLMNAHSD17B10ALDH1A1MAPK1 | |
| SCHEMBL12647098 | 0.77 | MAPT (1.00) | MAPTLMNAHSD17B10ALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009103022-A1 | DERIVATIVES OF SUBSTITUTED FUSED RING CYCLOINDOLES AND METHODS OF THEIR USE | ITHERX PHARMACEUTICALS, INC. (US) | 2009-08-20 | — | — | WO | disclosed |
| WO-2009103022-A1 | DERIVATIVES OF SUBSTITUTED FUSED RING CYCLOINDOLES AND METHODS OF THEIR USE | ITHERX PHARMACEUTICALS, INC. (US) | 2009-08-20 | — | — | WO | disclosed |
| US-4725615-A | SELECTIVE FOR \"NEURONAL\" 5-HYDROXYTRYPTAMINE RECEPTORS; NERVOUS SYSTEM DISORDERS | GLAXO GROUP LIMITED | 1988-02-16 | — | — | US | disclosed |
| EP-0219193-A1 | Tetrahydrocarbazolone derivatives, processes for their preparation and pharmaceutical compositions containing them | GLAXO GROUP LIMITED (GB) | 1987-04-22 | — | — | EP | disclosed |