Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 2/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | GFER | P55789 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.50 |
| ▸ | PARP1 | P09874 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 4/20 | 0.49 |
| ▸ | HTR6 | P50406 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4104903 | 0.89 | KDR (0.55) | KDRALDH1A1KDM4EHSD17B10MAPT | |
| SCHEMBL2303878 | 0.81 | ALDH1A1 (0.60) | KDRALDH1A1KDM4EHSD17B10MAPT | |
| SCHEMBL4279959 | 0.79 | LMNA (0.67) | KDRALDH1A1KDM4EHSD17B10MAPT | |
| SCHEMBL31451663 | 0.79 | KDR (0.85) | KDRALDH1A1KDM4EHSD17B10MAPT | |
| SCHEMBL9672176 | 0.78 | MAOB (0.55) | ALDH1A1KDM4ELMNAPOLBTDP1 | |
| SCHEMBL21758537 | 0.78 | KDR (0.53) | KDRALDH1A1KDM4EHSD17B10MAPT | |
| SCHEMBL4025232 | 0.78 | MAPT (0.62) | KDRALDH1A1KDM4EHSD17B10MAPT | |
| SCHEMBL6921570 | 0.78 | DYRK1A (0.46) | KDRALDH1A1KDM4ELMNAHPGD | |
| SCHEMBL2301312 | 0.78 | LMNA (0.60) | KDRALDH1A1KDM4EHSD17B10MEN1 | |
| SCHEMBL12284690 | 0.77 | HSD17B10 (0.63) | KDRALDH1A1KDM4EHSD17B10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6514968-B1 | Treating a disease or condition in a mammal wherein the 5-HT receptor is implicated and modulation of 5-HT function is desired comprising | PHARMACIA & UPJOHN COMPANY | 2003-02-04 | — | — | US | disclosed |
| EP-1210329-A2 | AMINOALKOXY CARBAZOLES AND THEIR USE AS 5-HT LIGANDS | PHARMACIA & UPJOHN COMPANY (US) | 2002-06-05 | — | — | EP | disclosed |
| WO-2001017963-A2 | AMINOALKOXY CARBAZOLES AND THEIR USE AS 5-HT LIGANDS | PHARMACIA & UPJOHN COMPANY (US) | 2001-03-15 | — | — | WO | disclosed |
| US-4725615-A | SELECTIVE FOR \"NEURONAL\" 5-HYDROXYTRYPTAMINE RECEPTORS; NERVOUS SYSTEM DISORDERS | GLAXO GROUP LIMITED | 1988-02-16 | — | — | US | disclosed |
| EP-0219193-A1 | Tetrahydrocarbazolone derivatives, processes for their preparation and pharmaceutical compositions containing them | GLAXO GROUP LIMITED (GB) | 1987-04-22 | — | — | EP | disclosed |