SCHEMBL4025318

SCHEMBL4025318

N#Cc1cc(Br)c(N)cc1C(F)(F)F

nearest known ligand 0.41

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
AR P10275 19/20 0.41
PGR P06401 2/20 0.37
CA12 O43570 1/20 0.37
CA1 P00915 1/20 0.37
CA2 P00918 1/20 0.37
CA4 P22748 1/20 0.37
CA6 P23280 1/20 0.37
CA5A P35218 1/20 0.37
CA7 P43166 1/20 0.37
CA9 Q16790 1/20 0.37
CA14 Q9ULX7 1/20 0.37
CA5B Q9Y2D0 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29502009 1.00 AR (0.41) ARPGRCA12CA1CA2
SCHEMBL324217 0.85 AR (0.47) ARPGR
SCHEMBL1259671 0.84 AR (0.46) ARPGR
SCHEMBL28392970 0.84 AR (0.50) ARPGR
SCHEMBL203731 0.82 AR (0.44) ARPGR
SCHEMBL12495047 0.79 TRPV4 (0.42) ARPGR
SCHEMBL202518 0.78 AR (0.46) ARPGR
SCHEMBL26118753 0.78 AR (0.38) ARPGRCA12CA1CA2
SCHEMBL202385 0.78 AR (0.41) ARPGR
SCHEMBL9460722 0.78 MEN1 (0.41) CA12CA1CA2CA4CA6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12610730-B2 Metal complex and light emitting device CITY UNIVERSITY OF HONG KONG (HK) 2026-04-21 US disclosed
US-12479807-B2 Methods using HDAC11 inhibitors VALO HEALTH, INC. (US) 2025-11-25 US disclosed
CN-114315834-B Imidazolone derivatives and their use in medicine 成都百裕制药股份有限公司 2024-01-05 CN disclosed
US-20230165867-A1 IMIDAZOLIDINONE DERIVATIVES AND MEDICAL USE THEREOF KANGBAIDA (SICHUAN) BIOTECHNOLOGY CO., LTD. (CN) 2023-06-01 US disclosed
US-20230165867-A1 IMIDAZOLIDINONE DERIVATIVES AND MEDICAL USE THEREOF KANGBAIDA (SICHUAN) BIOTECHNOLOGY CO., LTD. (CN) 2023-06-01 US disclosed
EP-4137491-A1 IMIDAZOLINONE DERIVATIVE AND USE THEREOF IN MEDICINE Chengdu Baiyu Pharmaceutical Co., Ltd. (CN) 2023-02-22 EP disclosed
EP-4137491-A1 IMIDAZOLINONE DERIVATIVE AND USE THEREOF IN MEDICINE Chengdu Baiyu Pharmaceutical Co., Ltd. (CN) 2023-02-22 EP disclosed
US-20230006152-A1 METAL COMPLEX AND LIGHT EMITTING DEVICE CITY UNIVERSITY OF HONG KONG (HK) 2023-01-05 US disclosed
US-20220235018-A1 METHODS USING HDAC11 INHIBITORS Valo Health, LLC 2022-07-28 US disclosed
US-11345672-B2 Methods using HDAC11 inhibitors VALO HEALTH, INC. (US) 2022-05-31 US disclosed
US-20180127386-A1 METHODS USING HDAC11 INHIBITORS VALO EARLY DISCOVERY, INC. 2018-05-10 US disclosed
WO-2018075959-A1 METHODS USING HDAC11 INHIBITORS FORMA THERAPEUTICS, INC. (US) 2018-04-26 WO disclosed
WO-2018075959-A1 METHODS USING HDAC11 INHIBITORS FORMA THERAPEUTICS, INC. (US) 2018-04-26 WO disclosed
WO-2009097996-A1 USE OF SUBSTITUTED PHENYLIMIDAZOLIDINES FOR PRODUCING MEDICAMENTS FOR TREATING METABOLIC SYNDROME SANOFI-AVENTIS (FR) 2009-08-13 WO disclosed
CN-1044234-C New substituted phenylimidazolidines, their preparation process, their use as medicaments and the pharmaceutical compositions containing them ROUSSEL UCLAF (FR) 1999-07-21 CN disclosed
US-RE35956-E Phenylimidazolidines having antiandrogenic activity ROUSSEL UCLAF (FR) 1998-11-10 US disclosed
US-5627201-A Phenylimidazolidines having antiandrogenic activity ROUSSEL UCLAF (FR) 1997-05-06 US disclosed
US-5411981-A Phenylimidazolidines having antiandrogenic activity ROUSSEL UCLAF (FR) 1995-05-02 US disclosed
EP-0580459-A1 Substituted Phenylimidazolidins, process for their preparation, their use as medicaments and their pharmaceutical compositions containing them ROUSSEL UCLAF (FR) 1994-01-26 EP disclosed
CN-1081182-A The phenylimidazolidines, of new replacement, its preparation method, as the purposes of medicine and contain their pharmaceutical composition ROUSSEL UCLAF (FR) 1994-01-26 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11345672-B2 Methods using HDAC11 inhibitors HDAC11, HDAC1, HDAC10 AR 2064/4885PGR 3642/4885CA12 1912/4885
US-20180127386-A1 METHODS USING HDAC11 INHIBITORS HDAC11, HDAC1, HDAC10 AR 2064/4885PGR 3642/4885CA12 1912/4885
US-20230006152-A1 METAL COMPLEX AND LIGHT EMITTING DEVICE OCIAD1, OCIAD2, OPRD1 AR 2930/4885PGR 2689/4885CA12 2123/4885
US-12610730-B2 Metal complex and light emitting device OPRD1, OCIAD2, ORC3 AR 3577/4885PGR 1026/4885CA12 3950/4885
US-12479807-B2 Methods using HDAC11 inhibitors HDAC11, HDAC1, HDAC10 AR 2064/4885PGR 3642/4885CA12 1912/4885
US-20230165867-A1 IMIDAZOLIDINONE DERIVATIVES AND MEDICAL USE THEREOF SYMPK, PAICS, CYP2C9 AR 1176/4885PGR 1382/4885CA12 2071/4885
US-20220235018-A1 METHODS USING HDAC11 INHIBITORS HDAC11, HDAC1, HDAC10 AR 2064/4885PGR 3642/4885CA12 1912/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.