Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | CMA1 | P23946 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | GFER | P55789 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL243170 | 0.82 | ALOX15 (0.45) | SMN1; SMN2TSHRHSD17B10CMA1PKM | |
| SCHEMBL3573012 | 0.78 | CYP3A4 (0.38) | SMN1; SMN2CYP3A4CYP1A2TSHRHSD17B10 | |
| SCHEMBL4023755 | 0.73 | PIK3CD (0.54) | SMN1; SMN2CYP3A4CYP1A2TSHRHSD17B10 | |
| SCHEMBL3119596 | 0.70 | PIK3CD (0.56) | SMN1; SMN2HSD17B10PIK3CDPIK3CAPIK3CB | |
| SCHEMBL245119 | 0.70 | SCD (0.44) | RORC | |
| SCHEMBL243779 | 0.69 | SCD (0.60) | TSHRPKMRAB9AALDH1A1POLB | |
| SCHEMBL28779004 | 0.67 | RORC (0.36) | RORCSMN1; SMN2TSHRNPSR1RAB9A | |
| SCHEMBL242263 | 0.67 | EP300 (0.45) | RORCSMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL14047537 | 0.67 | NOTUM (0.36) | RORC | |
| SCHEMBL27756804 | 0.67 | RORC (0.44) | RORCSMN1; SMN2TSHRHSD17B10NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2054408-A2 | HETEROCYCLIC COMPOUNDS SUITABLE FOR THE TREATMENT OF DISEASES RELATED TO ELEVATED LIPID LEVEL | Novartis Ag (CH) | 2009-05-06 | — | — | EP | disclosed |
| WO-2008127349-A2 | HETEROCYCLIC COMPOUNDS SUITABLE FOR THE TREATMENT OF DISEASES RELATED TO ELEVATED LIPID LEVEL | NOVARTIS AG (CH) | 2008-10-23 | — | — | WO | disclosed |