Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.42 |
| ▸ | TP53 | P04637 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | HAVCR2 | Q8TDQ0 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5026464 | 0.81 | AR (0.52) | MAPTTP53LMNAEGFRAR | |
| SCHEMBL12480461 | 0.79 | L3MBTL1 (0.53) | ALDH1A1KDM4EHSD17B10POLBALOX15 | |
| SCHEMBL14040246 | 0.74 | AR (0.35) | ARMEN1NPC1RAB9AKMT2A | |
| SCHEMBL14041625 | 0.73 | AR (0.36) | AR | |
| SCHEMBL4029160 | 0.73 | GFER (0.47) | MAPTTP53LMNAEGFRMEN1 | |
| SCHEMBL4651210 | 0.72 | AR (0.36) | AR | |
| SCHEMBL4025604 | 0.72 | MAPT (0.43) | MAPTTP53LMNAMEN1NPC1 | |
| SCHEMBL4148253 | 0.72 | MAPT (0.56) | MAPTTP53LMNAEGFRMEN1 | |
| SCHEMBL28549389 | 0.70 | SMN1; SMN2 (0.50) | MAPTTP53LMNAEGFRALDH1A1 | |
| SCHEMBL6625805 | 0.70 | MAPT (0.44) | MAPTTP53LMNAEGFRAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1328515-B1 | INDOLINE DERIVATIVES AND THEIR USE AS 5-HT2 RECEPTOR LIGANDS | HOFFMANN LA ROCHE (CH) | 2008-08-06 | — | — | EP | disclosed |