Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GFER | P55789 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | MET | P08581 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | CASP6 | P55212 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | CASP1 | P29466 | 2/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6755332 | 0.84 | GFER (0.48) | GFERKDM4EALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL4025604 | 0.83 | MAPT (0.43) | KDM4EALDH1A1SMN1; SMN2MAPTLMNA | |
| SCHEMBL2485381 | 0.79 | GFER (0.60) | GFERKDM4EALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL11732994 | 0.77 | GFER (0.57) | GFERKDM4EALDH1A1MAPTHSD17B10 | |
| SCHEMBL7460360 | 0.76 | MEN1 (0.46) | GFERKDM4EALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL5017970 | 0.73 | MAPT (0.42) | KDM4EALDH1A1SMN1; SMN2MAPTLMNA | |
| SCHEMBL5026464 | 0.72 | AR (0.52) | GFERKDM4EALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL2804474 | 0.72 | GFER (0.44) | GFERKDM4EALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL29415431 | 0.72 | GFER (0.44) | GFERKDM4EALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL11742569 | 0.72 | GFER (0.58) | GFERKDM4EALDH1A1MAPTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009103022-A1 | DERIVATIVES OF SUBSTITUTED FUSED RING CYCLOINDOLES AND METHODS OF THEIR USE | ITHERX PHARMACEUTICALS, INC. (US) | 2009-08-20 | — | — | WO | disclosed |