Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 6/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | ERN1 | O75460 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | EP300 | Q09472 | 1/20 | 0.39 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.39 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | GALK1 | P51570 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4024851 | 0.77 | MAPT (0.43) | LMNACYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL4021056 | 0.74 | EP300 (0.51) | LMNACYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL4023574 | 0.72 | MAPT (0.62) | LMNAKDM4EALDH1A1MAPTGALK1 | |
| SCHEMBL4019913 | 0.72 | CHUK (0.45) | KDM4EALDH1A1MAPK10MAPTGALK1 | |
| SCHEMBL14357917 | 0.70 | HDAC1 (0.46) | KDM4EALDH1A1GLAGAAMAPT | |
| SCHEMBL9426430 | 0.70 | KDM4E (0.50) | KDM4EALDH1A1GLAGAAMAPT | |
| SCHEMBL12192639 | 0.70 | IKBKB (0.46) | CHUK | |
| Acetone SCHEMBL27493038 | 0.70 | IMPDH2 (0.45) | IMPDH2LMNACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL11741231 | 0.70 | MAPK10 (0.47) | IMPDH2CYP1A2MAPK10MAPTTRPV1 | |
| SCHEMBL7843617 | 0.70 | IMPDH2 (0.61) | IMPDH2LMNACYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1478363-B1 | FUSED AZABICYCLIC COMPOUNDS THAT INHIBIT VANILLOID RECEPTOR SUBTYPE 1 (VR1) RECEPTOR | ABBOTT LAB (US) | 2009-01-14 | — | — | EP | claimed |
| EP-1478363-B1 | FUSED AZABICYCLIC COMPOUNDS THAT INHIBIT VANILLOID RECEPTOR SUBTYPE 1 (VR1) RECEPTOR | ABBOTT LAB (US) | 2009-01-14 | — | — | EP | disclosed |