Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHUK | O15111 | 1/20 | 0.45 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.42 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.41 |
| ▸ | GALK1 | P51570 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | CLK1 | P49759 | 1/20 | 0.41 |
| ▸ | CLK2 | P49760 | 1/20 | 0.41 |
| ▸ | CLK3 | P49761 | 1/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.41 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.41 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 6/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20072220 | 0.84 | ALDH1A1 (0.47) | CHUKPRKCZPRKD2KDM4EMAPT | |
| SCHEMBL14503713 | 0.78 | POLB (0.49) | KDM4EMAPTALDH1A1 | |
| SCHEMBL4023574 | 0.77 | MAPT (0.62) | KDM4EMAPTGALK1ATMALDH1A1 | |
| SCHEMBL4023758 | 0.75 | CHUK (0.44) | CHUKKDM4EMAPTDYRK1ACLK1 | |
| SCHEMBL4021056 | 0.73 | EP300 (0.51) | CHUKKDM4EMAPTALDH1A1MAPK10 | |
| SCHEMBL9426430 | 0.73 | KDM4E (0.50) | CHUKKDM4EMAPTALDH1A1 | |
| SCHEMBL14357917 | 0.73 | HDAC1 (0.46) | CHUKKDM4EMAPTALDH1A1 | |
| SCHEMBL4026288 | 0.72 | IMPDH2 (0.49) | CHUKKDM4EMAPTGALK1ATM | |
| SCHEMBL25899546 | 0.72 | CHUK (0.43) | CHUKKDM4EALDH1A1MAP4K1MAPK10 | |
| Hydrochloric Acid SCHEMBL5749683 | 0.71 | HDAC1 (0.45) | CHUKKDM4EMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1478363-B1 | FUSED AZABICYCLIC COMPOUNDS THAT INHIBIT VANILLOID RECEPTOR SUBTYPE 1 (VR1) RECEPTOR | ABBOTT LAB (US) | 2009-01-14 | — | — | EP | claimed |
| EP-1478363-B1 | FUSED AZABICYCLIC COMPOUNDS THAT INHIBIT VANILLOID RECEPTOR SUBTYPE 1 (VR1) RECEPTOR | ABBOTT LAB (US) | 2009-01-14 | — | — | EP | disclosed |