Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PELI1 | Q96FA3 | 3/20 | 0.39 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.38 |
| ▸ | IP6K3 | Q96PC2 | 1/20 | 0.38 |
| ▸ | IP6K2 | Q9UHH9 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.37 |
| ▸ | CCNC | P24863 | 4/20 | 0.33 |
| ▸ | CDK8 | P49336 | 4/20 | 0.33 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.33 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4026316 | 1.00 | PELI1 (0.39) | PELI1IP6K1IP6K3IP6K2HDAC1 | |
| SCHEMBL4021497 | 0.86 | TTR (0.46) | IP6K1IP6K3IP6K2 | |
| SCHEMBL4021494 | 0.86 | TTR (0.46) | IP6K1IP6K3IP6K2 | |
| SCHEMBL4029918 | 0.83 | IP6K1 (0.38) | IP6K1IP6K2HDAC1HDAC2CCNC | |
| SCHEMBL4029915 | 0.83 | IP6K1 (0.38) | IP6K1IP6K2HDAC1HDAC2CCNC | |
| SCHEMBL4022857 | 0.76 | THRB (0.39) | HDAC1HDAC2CCNCCDK8HDAC6 | |
| SCHEMBL4026733 | 0.71 | CYP4F2 (0.35) | HDAC1HDAC2CCNCCDK8HDAC3 | |
| SCHEMBL16272297 | 0.70 | MMP1 (0.48) | KDM1ACYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL4026769 | 0.69 | MAPT (0.36) | — | |
| SCHEMBL3279060 | 0.68 | HCAR2 (0.47) | HDAC1HDAC2HDAC3CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537075-B1 | DIARYLUREA DERIVATIVES AND THEIR USE AS CHLORIDE CHANNEL BLOCKERS | NEUROSEARCH AS (DK) | 2009-07-01 | — | — | EP | disclosed |
| CN-100497302-C | Diarylurea derivatives and their use as chloride channel blockers | NEUROSEARCH AS (DK) | 2009-06-10 | — | — | CN | disclosed |
| US-20060160856-A1 | Diarylurea derivatives and their use as chloride channel blockers | NEUROSEARCH A/S (DK) | 2006-07-20 | — | — | US | disclosed |
| CN-1678573-A | Diaryl urea derivatives and their use as chlorine channel blockers | NEUROSEARCH AS (DK) | 2005-10-05 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060160856-A1 | Diarylurea derivatives and their use as chloride channel blockers | KIT, ORAI1, CACNA1C | PELI1 4418/4885IP6K1 1386/4885IP6K3 1704/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.