Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4F2 | P78329 | 1/20 | 0.35 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.34 |
| ▸ | PCNA | P12004 | 1/20 | 0.33 |
| ▸ | IGF1R | P08069 | 3/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.33 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.33 |
| ▸ | CDC25B | P30305 | 1/20 | 0.32 |
| ▸ | CASP6 | P55212 | 1/20 | 0.32 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4021388 | 0.86 | PTPN1 (0.40) | ALDH1A1KDM4EGAAMAPTHPGD | |
| SCHEMBL4022857 | 0.76 | THRB (0.39) | HPGDTSHRHDAC1HDAC6CCNC | |
| SCHEMBL4026316 | 0.71 | PELI1 (0.39) | HSD17B1HSD17B2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL4026319 | 0.71 | PELI1 (0.39) | HSD17B1HSD17B2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL4025972 | 0.71 | TERT (0.36) | CASP6 | |
| SCHEMBL4026769 | 0.69 | MAPT (0.36) | ALDH1A1MAPTHPGD | |
| SCHEMBL4021504 | 0.68 | HPGD (0.42) | ALDH1A1MAPTHPGDCYP1A2 | |
| SCHEMBL3745750 | 0.68 | HCAR2 (0.52) | HDAC1HDAC8 | |
| SCHEMBL4030744 | 0.68 | KDM4E (0.47) | ALDH1A1KDM4EMAPTHPGDHIF1A | |
| SCHEMBL3016713 | 0.68 | ALOX15 (0.49) | ALDH1A1KDM4EGAAMAPTALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537075-B1 | DIARYLUREA DERIVATIVES AND THEIR USE AS CHLORIDE CHANNEL BLOCKERS | NEUROSEARCH AS (DK) | 2009-07-01 | — | — | EP | disclosed |
| CN-100497302-C | Diarylurea derivatives and their use as chloride channel blockers | NEUROSEARCH AS (DK) | 2009-06-10 | — | — | CN | disclosed |
| US-20060160856-A1 | Diarylurea derivatives and their use as chloride channel blockers | NEUROSEARCH A/S (DK) | 2006-07-20 | — | — | US | disclosed |
| CN-1678573-A | Diaryl urea derivatives and their use as chlorine channel blockers | NEUROSEARCH AS (DK) | 2005-10-05 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060160856-A1 | Diarylurea derivatives and their use as chloride channel blockers | KIT, ORAI1, CACNA1C | CYP4F2 3623/4885CYP4A11 3877/4885ALDH1A1 1538/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.