Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | TSHR | P16473 | 4/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.44 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | GLS | O94925 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1012144 | 0.83 | KMT2A (0.53) | KDM4EFFAR2ALDH1A1HSD17B10MAPK1 | |
| SCHEMBL22793352 | 0.81 | GAA (0.54) | KDM4EALDH1A1LMNA | |
| SCHEMBL19116508 | 0.77 | SMN1; SMN2 (0.66) | KDM4EFFAR2ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL3272690 | 0.77 | FFAR2 (0.41) | FFAR2MEN1KMT2A | |
| SCHEMBL19111002 | 0.75 | FFAR2 (0.48) | FFAR2ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL19699538 | 0.74 | FFAR2 (0.61) | KDM4EFFAR2ALDH1A1TSHRMAPT | |
| SCHEMBL20935120 | 0.74 | SMN1; SMN2 (0.47) | KDM4EALDH1A1TSHRHSD17B10MAPK1 | |
| SCHEMBL4093611 | 0.74 | NAMPT (0.46) | FFAR2MEN1KMT2A | |
| SCHEMBL31038470 | 0.74 | NAMPT (0.46) | FFAR2MEN1KMT2A | |
| SCHEMBL20188582 | 0.74 | ALDH1A1 (0.53) | KDM4EALDH1A1TSHRHSD17B10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009095377-A1 | SPIRO COMPOUNDS AS NPY Y5 RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2009-08-06 | — | — | WO | disclosed |