Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM2B | Q8NHM5 | 8/20 | 0.40 |
| ▸ | KIF11 | P52732 | 1/20 | 0.38 |
| ▸ | MGLL | Q99685 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4780092 | 0.96 | KDM2B (0.43) | KDM2BKMT2AHTTDRD4HSD11B1 | |
| SCHEMBL4029041 | 0.93 | KDM4E (0.38) | KDM2BMGLLKMT2AMEN1ALDH1A1 | |
| SCHEMBL4338025 | 0.91 | KDM2B (0.41) | KDM2BMGLLKMT2AHTTHSD11B1 | |
| SCHEMBL4026114 | 0.91 | KDM2B (0.41) | KDM2BMGLLKMT2AHTTHSD11B1 | |
| SCHEMBL4338035 | 0.91 | KDM2B (0.41) | KDM2BMGLLKMT2AHTTHSD11B1 | |
| SCHEMBL4025770 | 0.91 | KDM2B (0.41) | KDM2BMGLLKMT2AHTTHSD11B1 | |
| SCHEMBL4779051 | 0.90 | KDM4E (0.36) | KDM2BMGLLKMT2AMEN1ALDH1A1 | |
| SCHEMBL4021139 | 0.90 | KDM2B (0.43) | KDM2BMGLLKMT2AHTTESR1 | |
| SCHEMBL4019102 | 0.88 | ACHE (0.37) | KIF11MGLLDRD4ALDH1A1 | |
| SCHEMBL4025347 | 0.88 | KIF11 (0.37) | KIF11DRD4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7572814-B2 | 3,5-dibenzoyl-4-phenyl-piperidine anti-cancer compounds | CYTOKINETICS, INCORPORATED (US) | 2009-08-11 | — | — | US | claimed |
| EP-1962846-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2008-09-03 | — | — | EP | claimed |
| WO-2007059323-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2007-05-24 | — | — | WO | claimed |