Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERCC1 | P07992 | 3/20 | 0.45 |
| ▸ | FEN1 | P39748 | 3/20 | 0.45 |
| ▸ | ERCC4 | Q92889 | 3/20 | 0.45 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | POLB | P06746 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4028038 | 1.00 | ERCC1 (0.45) | ERCC1FEN1ERCC4RNASEH1ALDH1A1 | |
| SCHEMBL4034573 | 0.90 | ERCC1 (0.57) | ERCC1FEN1ERCC4ALDH1A1MEN1 | |
| SCHEMBL4028792 | 0.90 | ERCC1 (0.57) | ERCC1FEN1ERCC4ALDH1A1MEN1 | |
| SCHEMBL4026532 | 0.86 | ERCC1 (0.33) | ERCC1FEN1ERCC4ALDH1A1CYP2C19 | |
| SCHEMBL4029963 | 0.85 | ERCC1 (0.45) | ERCC1FEN1ERCC4RNASEH1ALDH1A1 | |
| SCHEMBL4028795 | 0.83 | ERCC1 (0.39) | ERCC1FEN1ERCC4ALDH1A1MEN1 | |
| SCHEMBL4030167 | 0.79 | ERCC1 (0.46) | ERCC1FEN1ERCC4RNASEH1ALDH1A1 | |
| SCHEMBL6450711 | 0.78 | ERCC1 (0.45) | ERCC1FEN1ERCC4RNASEH1ALDH1A1 | |
| SCHEMBL22078872 | 0.77 | ERCC1 (0.56) | ERCC1FEN1ERCC4RNASEH1ALDH1A1 | |
| SCHEMBL4028581 | 0.76 | ERCC1 (0.44) | ERCC1FEN1ERCC4RNASEH1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1470113-B1 | PYRIMIDINONE VIRAL POLYMERASE INHIBITORS | ANGELETTI P IST RICHERCHE BIO (IT) | 2009-01-07 | — | — | EP | disclosed |
| US-20050130997-A1 | Pyrimidinone viral polymerase inhibitors | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2005-06-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050130997-A1 | Pyrimidinone viral polymerase inhibitors | POLR2A, POLR1E, POLR2E | ERCC1 3181/4885FEN1 343/4885ERCC4 1663/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.