Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | RORC | P51449 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4021517 | 1.00 | HRH3 (0.42) | HRH3KMT2AMEN1RORCALDH1A1 | |
| SCHEMBL4019022 | 0.85 | KIF11 (0.37) | HRH3RORCALDH1A1SIGMAR1 | |
| SCHEMBL4025183 | 0.85 | KIF11 (0.37) | HRH3RORCALDH1A1SIGMAR1 | |
| SCHEMBL13721498 | 0.84 | HRH3 (0.45) | HRH3KMT2AMEN1RORCALDH1A1 | |
| SCHEMBL4028249 | 0.84 | HRH3 (0.45) | HRH3KMT2AMEN1RORCALDH1A1 | |
| SCHEMBL4772338 | 0.84 | HRH3 (0.45) | HRH3KMT2AMEN1RORCALDH1A1 | |
| SCHEMBL4027487 | 0.84 | HRH3 (0.45) | HRH3KMT2AMEN1RORCALDH1A1 | |
| SCHEMBL4027493 | 0.84 | HRH3 (0.45) | HRH3KMT2AMEN1RORCALDH1A1 | |
| SCHEMBL4020945 | 0.81 | ALDH1A1 (0.51) | KMT2AALDH1A1GAALMNACYP2C19 | |
| SCHEMBL4019459 | 0.80 | RORC (0.57) | KMT2AMEN1RORCALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1962846-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007059323-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2007-05-24 | — | — | WO | disclosed |