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Sugi Predict / Compounds / SCHEMBL4028356

SCHEMBL4028356

SCHEMBL4028356

Cc1c(C(=O)N(C)C)cc(C(=O)NCc2csc3ccccc23)c(=O)n1-c1cccc(C(F)(F)F)c1

nearest known ligand 0.46

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ ELANE P08246 6/20 0.46
▸ CCR1 P32246 5/20 0.42
▸ TP53 P04637 2/20 0.42
▸ MAPT P10636 2/20 0.42
▸ NOTUM Q6P988 1/20 0.40
▸ PMM2 O15305 1/20 0.39
▸ MPI P34949 1/20 0.39
▸ PHOSPHO1 Q8TCT1 1/20 0.39
▸ ALDH1A1 P00352 3/20 0.39
▸ NPSR1 Q6W5P4 2/20 0.39
▸ HPGD P15428 1/20 0.39
▸ KMT2A Q03164 1/20 0.39
▸ SMN1; SMN2 Q16637 2/20 0.38
▸ LMNA P02545 1/20 0.37
▸ DDT P30046 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4025359 0.87 ELANE (0.48) ELANECCR1TP53MAPTNOTUM
SCHEMBL4021451 0.85 ELANE (0.56) ELANECCR1NOTUMALDH1A1HPGD
SCHEMBL5757767 0.85 ELANE (0.63) ELANECCR1TP53MAPTNOTUM
SCHEMBL23068742 0.84 ELANE (0.44) ELANECCR1MAPTNOTUMPMM2
SCHEMBL11895339 0.83 ELANE (0.50) ELANECCR1NOTUMALDH1A1HPGD
SCHEMBL5448241 0.82 PLA2G10 (0.46) ELANECCR1TP53MAPTPMM2
SCHEMBL11895652 0.82 ELANE (0.47) ELANECCR1TP53MAPTNOTUM
SCHEMBL11894815 0.81 ELANE (0.54) ELANECCR1NOTUMALDH1A1DDT
SCHEMBL4021150 0.81 ELANE (0.53) ELANECCR1NOTUMALDH1A1HPGD
SCHEMBL4024102 0.80 CCR1 (0.45) ELANECCR1TP53NOTUM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10092552-B2 Aerosol pirfenidone and pyridone analog compounds and uses thereof AVALYN PHARMA INC. (US) 2018-10-09 — — US disclosed
US-20170224706-A1 AEROSOL PIRFENIDONE AND PYRIDONE ANALOG COMPOUNDS AND USES THEREOF GENOA PHARMACEUTICALS, INC. 2017-08-10 — — US disclosed
US-20120192861-A1 AEROSOL PIRFENIDONE AND PYRIDONE ANALOG COMPOUNDS AND USES THEREOF GENOA PHARMACEUTICALS, INC. (US) 2012-08-02 — — US disclosed
EP-1663974-B1 2-PYRIDONE DERIVATIVES AS NETROPHIL ELASTASE INHIBITORS AND THEIR USE ASTRAZENECA AB (SE) 2009-01-14 — — EP disclosed
US-20070043036-A1 2-Pyridone derivatives as neutrophil elastase inhibitors and their use ASTRAZENECA AB (SE) 2007-02-22 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070043036-A1 2-Pyridone derivatives as neutrophil elastase inhibitors and their use SERPINB1, ELANE, SERPINE1 ELANE 2/4885CCR1 211/4885TP53 3519/4885
US-20120192861-A1 AEROSOL PIRFENIDONE AND PYRIDONE ANALOG COMPOUNDS AND USES THEREOF PLPBP, PIR, PDXK ELANE 1574/4885CCR1 1988/4885TP53 2558/4885
US-20170224706-A1 AEROSOL PIRFENIDONE AND PYRIDONE ANALOG COMPOUNDS AND USES THEREOF PLPBP, PIR, PDXK ELANE 1574/4885CCR1 1988/4885TP53 2558/4885
US-10092552-B2 Aerosol pirfenidone and pyridone analog compounds and uses thereof PLPBP, PIR, PDXK ELANE 1574/4885CCR1 1988/4885TP53 2558/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.