Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.79 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.79 |
| ▸ | PKM | P14618 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | CTBP2 | P56545 | 1/20 | 0.47 |
| ▸ | TLR4 | O00206 | 2/20 | 0.45 |
| ▸ | XDH | P47989 | 2/20 | 0.45 |
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.45 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | MGLL | Q99685 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4028381 | 1.00 | SMN1; SMN2 (0.79) | SMN1; SMN2KDM4EPKMGAACTBP2 | |
| SCHEMBL9564540 | 0.89 | SMN1; SMN2 (1.00) | SMN1; SMN2KDM4EPKMCTBP2TLR4 | |
| SCHEMBL4807375 | 0.81 | KDM4E (0.50) | SMN1; SMN2KDM4ECTBP2TLR4XDH | |
| SCHEMBL4216593 | 0.81 | SMN1; SMN2 (0.84) | SMN1; SMN2KDM4EPKMCTBP2ALDH1A1 | |
| SCHEMBL6169609 | 0.81 | KDM4E (0.50) | SMN1; SMN2KDM4EXDHCYP1A2ALDH1A1 | |
| SCHEMBL28303440 | 0.81 | SMN1; SMN2 (0.84) | SMN1; SMN2KDM4EPKMCTBP2TLR4 | |
| SCHEMBL4216595 | 0.81 | SMN1; SMN2 (0.84) | SMN1; SMN2KDM4EPKMCTBP2ALDH1A1 | |
| SCHEMBL6169610 | 0.81 | KDM4E (0.50) | SMN1; SMN2KDM4EXDHCYP1A2ALDH1A1 | |
| SCHEMBL4807381 | 0.81 | KDM4E (0.50) | SMN1; SMN2KDM4ECTBP2TLR4XDH | |
| SCHEMBL7839551 | 0.79 | HTT (0.60) | SMN1; SMN2PKMGAAMAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1492773-B1 | 4-(HETEROCYCLYL)-BENZENESULFOXIMINE COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | CADILA HEALTHCARE LTD (IN) | 2009-02-04 | — | — | EP | disclosed |
| US-7348342-B2 | Heterocyclic compounds process for their preparation and pharmaceutical compositions containing them and their use in medicine | CADILA HEALTHCARE LIMITED (IN) | 2008-03-25 | — | — | US | disclosed |
| US-20050277678-A1 | Heterocyclic compounds process for their preparation and pharmceutical compositions containing them and their use in medicine | CADILA HEALTHCARE LIMITED (IN) | 2005-12-15 | — | — | US | disclosed |
| EP-1492773-A2 | 4-(HETEROCYCLYL)-BENZENESULFOXIMINE COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | CADILA HEALTHCARE LTD. (IN) | 2005-01-05 | — | — | EP | disclosed |
| WO-2003087062-A2 | 4-(HETEROCYCLYL)-BENZENESULFOXIMINE COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | CADILA HEALTHCARE LIMITED (IN) | 2003-10-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050277678-A1 | Heterocyclic compounds process for their preparation and pharmceutical compositions containing them and their use in medicine | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, HPGDS, LTC4S | SMN1; SMN2 4204/4885KDM4E 2772/4885PKM 396/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.