Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.41 |
| ▸ | CTSL | P07711 | 1/20 | 0.41 |
| ▸ | XDH | P47989 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4807381 | 1.00 | KDM4E (0.50) | KDM4ESMN1; SMN2ALDH1A1HPGDMAPT | |
| SCHEMBL6169609 | 0.93 | KDM4E (0.50) | KDM4ESMN1; SMN2ALDH1A1HPGDMAPT | |
| SCHEMBL6169610 | 0.93 | KDM4E (0.50) | KDM4ESMN1; SMN2ALDH1A1HPGDMAPT | |
| SCHEMBL257218 | 0.82 | CTSL (0.55) | KDM4ESMN1; SMN2TSHRALOX12CTSL | |
| SCHEMBL4586154 | 0.82 | CTSL (0.55) | KDM4ESMN1; SMN2TSHRALOX12CTSL | |
| SCHEMBL4586157 | 0.82 | CTSL (0.55) | KDM4ESMN1; SMN2TSHRALOX12CTSL | |
| SCHEMBL4028381 | 0.81 | SMN1; SMN2 (0.79) | KDM4ESMN1; SMN2ALDH1A1MAPTXDH | |
| SCHEMBL4028385 | 0.81 | SMN1; SMN2 (0.79) | KDM4ESMN1; SMN2ALDH1A1MAPTXDH | |
| SCHEMBL13853886 | 0.81 | KDM4E (0.54) | KDM4ESMN1; SMN2KMT2ATSHRALOX12 | |
| SCHEMBL8407033 | 0.79 | MGLL (0.58) | KDM4ESMN1; SMN2LMNATSHRALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7329401-B2 | Cyclooxygenase-2 selective agents useful as imaging probes and related methods | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2008-02-12 | — | — | US | disclosed |
| US-7329401-B2 | Cyclooxygenase-2 selective agents useful as imaging probes and related methods | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2008-02-12 | — | — | US | disclosed |
| US-20070286801-A1 | CYCLOOXYGENASE-2 SELECTIVE AGENTS USEFUL AS IMAGING PROBES AND RELATED METHODS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2007-12-13 | — | — | US | disclosed |
| US-20070286801-A1 | CYCLOOXYGENASE-2 SELECTIVE AGENTS USEFUL AS IMAGING PROBES AND RELATED METHODS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2007-12-13 | — | — | US | disclosed |
| WO-2003089013-A1 | CYCLOOXYGENASE-2 SELECTIVE AGENTS USEFUL AS IMAGING PROBES AND RELATED METHODS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2003-10-30 | — | — | WO | disclosed |
| US-6596445-B1 | Initiators for photopolymerization of radically polymerizable compounds | CIBA SPECIALTY CHEMICALS CORPORATION | 2003-07-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070286801-A1 | CYCLOOXYGENASE-2 SELECTIVE AGENTS USEFUL AS IMAGING PROBES AND RELATED METHODS | PTGS2, PTGES2, PTGER2 | KDM4E 4237/4885SMN1; SMN2 3034/4885ALDH1A1 1070/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.