Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.38 |
| ▸ | SPR | P35270 | 9/20 | 0.35 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 2/20 | 0.32 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.32 |
| ▸ | PDE2A | O00408 | 3/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4028389 | 1.00 | BRD4 (0.38) | BRD4CREBBPSPRMDM2DYRK1A | |
| SCHEMBL13746821 | 0.87 | BRD4 (0.36) | BRD4CREBBPSPRDYRK1AGRIA1 | |
| SCHEMBL13747129 | 0.80 | TYMS (0.38) | CA12PDE2ACA2 | |
| SCHEMBL13746898 | 0.77 | HSD11B1 (0.39) | PDE2A | |
| SCHEMBL13746091 | 0.77 | DYRK1A (0.35) | SPRDYRK1AGRIA1PDE2A | |
| SCHEMBL4020404 | 0.76 | PDE2A (0.49) | GRIA1PDE2A | |
| SCHEMBL13746667 | 0.76 | PDE2A (0.37) | SPRPDE2A | |
| SCHEMBL4023129 | 0.75 | PDE2A (0.37) | SPRPDE2A | |
| SCHEMBL4023133 | 0.75 | PDE2A (0.37) | SPRPDE2A | |
| SCHEMBL13746127 | 0.75 | IRAK4 (0.44) | PDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009100403-A1 | SUBSTITUTED ARYL PYRIMIDINONES | NEUROGEN CORPORATION (US) | 2009-08-13 | — | — | WO | disclosed |