Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 9/20 | 0.49 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
| ▸ | GRIA1 | P42261 | 3/20 | 0.37 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.35 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.35 |
| ▸ | PLAT | P00750 | 1/20 | 0.34 |
| ▸ | PDE9A | O76083 | 2/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13746667 | 0.87 | PDE2A (0.37) | PDE2API4KBPIK3CA | |
| SCHEMBL13746012 | 0.85 | PIK3CA (0.36) | PDE2AKDM5BPI4KBPDE9APIK3CA | |
| SCHEMBL4023133 | 0.84 | PDE2A (0.37) | PDE2API4KB | |
| SCHEMBL4023129 | 0.84 | PDE2A (0.37) | PDE2API4KB | |
| SCHEMBL13747129 | 0.82 | TYMS (0.38) | PDE2APLAT | |
| SCHEMBL13746898 | 0.80 | HSD11B1 (0.39) | PDE2APDE9A | |
| SCHEMBL13746627 | 0.78 | USP1 (0.34) | PDE2APIK3CA | |
| SCHEMBL13746091 | 0.77 | DYRK1A (0.35) | PDE2AGRIA1 | |
| SCHEMBL4028389 | 0.76 | BRD4 (0.38) | PDE2AGRIA1 | |
| SCHEMBL4028394 | 0.76 | BRD4 (0.38) | PDE2AGRIA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009100403-A1 | SUBSTITUTED ARYL PYRIMIDINONES | NEUROGEN CORPORATION (US) | 2009-08-13 | — | — | WO | disclosed |
| WO-2009100403-A1 | SUBSTITUTED ARYL PYRIMIDINONES | NEUROGEN CORPORATION (US) | 2009-08-13 | — | — | WO | disclosed |