Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 12/20 | 0.56 |
| ▸ | MAPK11 | Q15759 | 10/20 | 0.56 |
| ▸ | MAPK13 | O15264 | 9/20 | 0.56 |
| ▸ | MAPK12 | P53778 | 9/20 | 0.56 |
| ▸ | RAF1 | P04049 | 3/20 | 0.56 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.56 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.52 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.52 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.52 |
| ▸ | BRAF | P15056 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.42 |
| ▸ | GCGR | P47871 | 1/20 | 0.42 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4033802 | 0.90 | CSNK1A1 (0.58) | MAPK14MAPK11MAPK13MAPK12RAF1 | |
| SCHEMBL4028406 | 0.87 | MAPK14 (0.59) | MAPK14MAPK11MAPK13MAPK12RAF1 | |
| SCHEMBL4032460 | 0.81 | MAPK11 (0.66) | MAPK14MAPK11MAPK13MAPK12RAF1 | |
| SCHEMBL4024247 | 0.81 | MAPK11 (0.66) | MAPK14MAPK11MAPK13MAPK12RAF1 | |
| SCHEMBL4025352 | 0.81 | CSNK1A1 (0.60) | MAPK14MAPK11MAPK13MAPK12RAF1 | |
| SCHEMBL4584849 | 0.81 | CSNK1A1 (0.60) | MAPK14MAPK11MAPK13MAPK12RAF1 | |
| SCHEMBL4030967 | 0.80 | MAPK11 (0.67) | MAPK14MAPK11MAPK13MAPK12RAF1 | |
| SCHEMBL4028779 | 0.79 | MAPK14 (0.71) | MAPK14MAPK11MAPK13MAPK12RAF1 | |
| SCHEMBL4025777 | 0.78 | BRAF (0.47) | MAPK14MAPK11MAPK13MAPK12MAPK9 | |
| SCHEMBL8601591 | 0.77 | MAPK14 (0.55) | MAPK14MAPK11MAPK13MAPK12RAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0854870-B1 | SUBSTITUTED IMIDAZOLES HAVING ANTI-CANCER AND CYTOKINE INHIBITORY ACTIVITY | MERCK & CO INC (US) | 2009-06-10 | — | — | EP | claimed |