Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.58 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.58 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.58 |
| ▸ | MAPK14 | Q16539 | 12/20 | 0.58 |
| ▸ | MAPK11 | Q15759 | 10/20 | 0.58 |
| ▸ | MAPK13 | O15264 | 9/20 | 0.58 |
| ▸ | MAPK12 | P53778 | 9/20 | 0.58 |
| ▸ | RAF1 | P04049 | 3/20 | 0.58 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.58 |
| ▸ | BRAF | P15056 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.44 |
| ▸ | GCGR | P47871 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4028673 | 0.90 | MAPK14 (0.56) | CSNK1A1CSNK1DRPS6KA3MAPK14MAPK11 | |
| SCHEMBL4025352 | 0.87 | CSNK1A1 (0.60) | CSNK1A1CSNK1DRPS6KA3MAPK14MAPK11 | |
| SCHEMBL4584849 | 0.87 | CSNK1A1 (0.60) | CSNK1A1CSNK1DRPS6KA3MAPK14MAPK11 | |
| SCHEMBL4028810 | 0.84 | MAPK13 (0.43) | CSNK1A1CSNK1DRPS6KA3MAPK14MAPK11 | |
| SCHEMBL4025777 | 0.83 | BRAF (0.47) | CSNK1A1CSNK1DRPS6KA3MAPK14MAPK11 | |
| SCHEMBL4028406 | 0.81 | MAPK14 (0.59) | CSNK1A1CSNK1DRPS6KA3MAPK14MAPK11 | |
| SCHEMBL4025331 | 0.81 | CSNK1A1 (0.67) | CSNK1A1CSNK1DRPS6KA3MAPK14MAPK11 | |
| SCHEMBL4025214 | 0.81 | CSNK1A1 (0.67) | CSNK1A1CSNK1DRPS6KA3MAPK14MAPK11 | |
| SCHEMBL4026671 | 0.80 | MAPK11 (0.68) | CSNK1A1CSNK1DRPS6KA3MAPK14MAPK11 | |
| SCHEMBL4024836 | 0.79 | CSNK1A1 (0.74) | CSNK1A1CSNK1DRPS6KA3MAPK14MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0854870-B1 | SUBSTITUTED IMIDAZOLES HAVING ANTI-CANCER AND CYTOKINE INHIBITORY ACTIVITY | MERCK & CO INC (US) | 2009-06-10 | — | — | EP | claimed |