Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 11/20 | 0.55 |
| ▸ | MAPK13 | O15264 | 9/20 | 0.55 |
| ▸ | MAPK12 | P53778 | 9/20 | 0.55 |
| ▸ | MAPK11 | Q15759 | 9/20 | 0.55 |
| ▸ | RAF1 | P04049 | 3/20 | 0.55 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.55 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.51 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.51 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.51 |
| ▸ | BRAF | P15056 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.44 |
| ▸ | GCGR | P47871 | 1/20 | 0.44 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8603194 | 0.89 | MAPK11 (0.61) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL8604215 | 0.89 | CSNK1A1 (0.53) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL28152166 | 0.86 | OPRD1 (0.48) | — | |
| SCHEMBL8602866 | 0.84 | USP30 (0.45) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL4025352 | 0.83 | CSNK1A1 (0.60) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL4584849 | 0.83 | CSNK1A1 (0.60) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL4029509 | 0.83 | CSNK1A1 (0.43) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL4028406 | 0.83 | MAPK14 (0.59) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL7815274 | 0.83 | CYP3A4 (0.39) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL7818989 | 0.81 | CYP3A4 (0.38) | MAPK14MAPK13MAPK12MAPK11RAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5717100-A | Substituted imidazoles having anti-cancer and cytokine inhibitory activity | MERCK & CO., INC. (US) | 1998-02-10 | — | — | US | disclosed |