Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 3/20 | 0.43 |
| ▸ | RAF1 | P04049 | 3/20 | 0.43 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.43 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.43 |
| ▸ | CDC7 | O00311 | 1/20 | 0.42 |
| ▸ | KIT | P10721 | 6/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.39 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.39 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 3/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4025591 | 0.88 | HTT (0.47) | MAPK13RAF1MAPK12MAPK11MAPK14 | |
| SCHEMBL4033802 | 0.84 | CSNK1A1 (0.58) | MAPK13RAF1MAPK12MAPK11MAPK14 | |
| SCHEMBL8576094 | 0.83 | MAPK14 (0.51) | MAPK13RAF1MAPK12MAPK11MAPK14 | |
| SCHEMBL13810545 | 0.82 | MAPK11 (0.53) | MAPK13RAF1MAPK12MAPK11MAPK14 | |
| SCHEMBL8602866 | 0.80 | USP30 (0.45) | MAPK13RAF1MAPK12MAPK11MAPK14 | |
| SCHEMBL13810546 | 0.77 | MAPK13 (0.46) | MAPK13RAF1MAPK12MAPK11MAPK14 | |
| SCHEMBL4028673 | 0.74 | MAPK14 (0.56) | MAPK13RAF1MAPK12MAPK11MAPK14 | |
| SCHEMBL3099823 | 0.72 | HTT (0.59) | ALDH1A1 | |
| SCHEMBL27538196 | 0.72 | MAPK14 (0.47) | MAPK14CDC7ALOX5CSNK1A1CSNK1D | |
| SCHEMBL4584849 | 0.71 | CSNK1A1 (0.60) | MAPK13RAF1MAPK12MAPK11MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0854870-B1 | SUBSTITUTED IMIDAZOLES HAVING ANTI-CANCER AND CYTOKINE INHIBITORY ACTIVITY | MERCK & CO INC (US) | 2009-06-10 | — | — | EP | claimed |