Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 16/20 | 0.54 |
| ▸ | HTR2C | P28335 | 1/20 | 0.54 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.48 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5132218 | 0.88 | MAPK1 (0.62) | MCHR1HTR2CLTB4RPRSS1MAPK1 | |
| SCHEMBL28450295 | 0.82 | PRSS1 (0.54) | PRSS1MAPK1 | |
| SCHEMBL28455576 | 0.78 | TP53 (0.51) | PRSS1MAPK1 | |
| SCHEMBL28463720 | 0.77 | TP53 (0.46) | PRSS1MAPK1 | |
| SCHEMBL6174553 | 0.77 | MCHR1 (0.55) | MCHR1HTR2C | |
| SCHEMBL4028851 | 0.75 | FDPS (0.58) | MAPK1 | |
| SCHEMBL4198415 | 0.75 | GAA (0.55) | MCHR1HTR2C | |
| SCHEMBL6806735 | 0.73 | MCHR1 (0.51) | MCHR1HTR2C | |
| SCHEMBL14558165 | 0.73 | TSHR (0.59) | MCHR1HTR2CLTB4R | |
| SCHEMBL6204180 | 0.72 | GAA (0.47) | MCHR1HTR2CMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1648448-A4 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2009-04-01 | — | — | EP | disclosed |
| EP-1648448-A1 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-04-26 | — | — | EP | disclosed |
| WO-2005011681-A1 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-02-10 | — | — | WO | disclosed |