Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 16/20 | 0.55 |
| ▸ | HTR2C | P28335 | 1/20 | 0.55 |
| ▸ | FDPS | P14324 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5132218 | 0.81 | MAPK1 (0.62) | MCHR1HTR2C | |
| SCHEMBL4028849 | 0.77 | MCHR1 (0.54) | MCHR1HTR2C | |
| SCHEMBL6920748 | 0.72 | MCHR1 (0.71) | MCHR1HTR2C | |
| SCHEMBL4198415 | 0.71 | GAA (0.55) | MCHR1HTR2CMAPT | |
| SCHEMBL31373860 | 0.71 | DRD2 (0.67) | MCHR1HPGDLMNADRD2DRD3 | |
| SCHEMBL6925349 | 0.71 | MCHR1 (0.81) | MCHR1HTR2C | |
| SCHEMBL6926509 | 0.71 | MCHR1 (1.00) | MCHR1HTR2C | |
| SCHEMBL6619884 | 0.69 | TAS1R3 (0.53) | MCHR1HTR2CLMNADRD2DRD3 | |
| SCHEMBL6806735 | 0.69 | MCHR1 (0.51) | MCHR1HTR2C | |
| SCHEMBL5132224 | 0.69 | MCHR1 (0.59) | MCHR1HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1397354-B1 | IMIDAZOLE-2-CARBOXAMIDE DERIVATIVES AS RAF KINASE INHIBITORS | SMITHKLINE BEECHAM PLC (GB) | 2005-10-26 | — | — | EP | disclosed |