Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS | P14324 | 3/20 | 0.58 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | APP | P05067 | 3/20 | 0.54 |
| ▸ | SNCA | P37840 | 1/20 | 0.54 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.53 |
| ▸ | ACHE | P22303 | 7/20 | 0.53 |
| ▸ | BCHE | P06276 | 5/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30560923 | 0.81 | KDM4E (0.75) | FDPSKDM4ESNCANFE2L2ACHE | |
| SCHEMBL8153885 | 0.81 | KDM4E (0.75) | FDPSKDM4ESNCANFE2L2ACHE | |
| SCHEMBL8153880 | 0.81 | KDM4E (0.75) | FDPSKDM4ESNCANFE2L2ACHE | |
| SCHEMBL5132218 | 0.79 | MAPK1 (0.62) | MAPK1 | |
| SCHEMBL29407280 | 0.77 | HDAC1 (0.64) | KDM4ESNCANFE2L2ALDH1A1HPGD | |
| SCHEMBL18570142 | 0.76 | FDPS (0.61) | FDPSKDM4EAPPSNCANFE2L2 | |
| SCHEMBL11759945 | 0.76 | ALDH1A1 (0.69) | FDPSKDM4ESNCANFE2L2ALDH1A1 | |
| SCHEMBL7606847 | 0.75 | SLC2A1 (0.69) | SLC2A1ACHEBCHEMEN1KMT2A | |
| SCHEMBL7606852 | 0.75 | SLC2A1 (0.69) | SLC2A1ACHEBCHEMEN1KMT2A | |
| SCHEMBL4028849 | 0.75 | MCHR1 (0.54) | MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1648448-A4 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2009-04-01 | — | — | EP | disclosed |
| EP-1648448-A1 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-04-26 | — | — | EP | disclosed |
| WO-2005011681-A1 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-02-10 | — | — | WO | disclosed |