Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 4/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6625805 | 0.83 | MAPT (0.44) | ARMAPTLMNATP53EGFR | |
| SCHEMBL5017970 | 0.81 | MAPT (0.42) | ARMAPTLMNATP53EGFR | |
| SCHEMBL2359673 | 0.78 | KDM4E (0.57) | ARMAPTHTR2AHTR2CHTR2B | |
| SCHEMBL5025185 | 0.76 | MAPT (0.39) | ARMAPTLMNATP53EGFR | |
| SCHEMBL4901767 | 0.73 | AR (0.39) | ARHTR2AHTR2CHTR2B | |
| SCHEMBL4909034 | 0.72 | SIRT1 (0.55) | ARMAPTALOX15MAPK1SMN1; SMN2 | |
| SCHEMBL4895997 | 0.72 | SIRT1 (0.44) | ARMEN1KMT2A | |
| SCHEMBL4029160 | 0.72 | GFER (0.47) | MAPTLMNATP53EGFRKDM4E | |
| SCHEMBL2359349 | 0.71 | AR (0.50) | ARMAPTHTR2AHTR2CLMNA | |
| SCHEMBL4148253 | 0.71 | MAPT (0.56) | MAPTLMNATP53EGFRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2510949-A1 | THERAPEUTIC AGENT FOR FIBROMYALGIA | Astellas Pharma Inc. (JP) | 2012-10-17 | — | — | EP | disclosed |
| EP-1328515-B1 | INDOLINE DERIVATIVES AND THEIR USE AS 5-HT2 RECEPTOR LIGANDS | HOFFMANN LA ROCHE (CH) | 2008-08-06 | — | — | EP | disclosed |