SCHEMBL4029191

SCHEMBL4029191

[CH2]C1(c2ccc(F)cc2)CCOCC1

nearest known ligand 0.39

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
HDAC3 O15379 1/20 0.38
HDAC1 Q13547 1/20 0.38
HDAC2 Q92769 1/20 0.38
HDAC6 Q9UBN7 1/20 0.38
MAOB P27338 2/20 0.36
MAOA P21397 1/20 0.36
SLC6A3 Q01959 3/20 0.36
LMNA P02545 1/20 0.35
SLC6A4 P31645 2/20 0.33
MMP1 P03956 1/20 0.33
MMP13 P45452 1/20 0.33
SLC6A2 P23975 1/20 0.33
CNR1 P21554 1/20 0.33
P2RX7 Q99572 1/20 0.33
EGFR P00533 2/20 0.33
HSD11B1 P28845 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9037762 0.80 SLC6A3 (0.48) MAOBMAOASLC6A3SLC6A4SLC6A2
Ammonia Solution, Strong SCHEMBL27575342 0.80 SLC6A3 (0.48) MAOBMAOASLC6A3SLC6A4SLC6A2
SCHEMBL26502704 0.75 HDAC3 (0.38) HDAC3HDAC1HDAC2HDAC6MAOB
SCHEMBL1240436 0.75 MAOB (0.41) HDAC3HDAC1HDAC2HDAC6MAOB
SCHEMBL14618820 0.71 HDAC6 (0.47) HDAC3HDAC1HDAC2HDAC6MAOB
SCHEMBL625655 0.71 OPRM1 (0.40) HDAC3HDAC1HDAC2HDAC6LMNA
SCHEMBL12614285 0.71 SLC6A3 (0.45) SLC6A3SLC6A4SLC6A2P2RX7HSD11B1
SCHEMBL2701757 0.71 SLC6A3 (0.68) MAOBMAOASLC6A3LMNASLC6A4
SCHEMBL166581 0.69 APP (0.50) HDAC3HDAC1HDAC2HDAC6LMNA
SCHEMBL11904240 0.69 MAOB (0.36) MAOBMAOASLC6A3LMNASLC6A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1501467-A4 HETEROCYCLO INHIBITORS OF POTASSIUM CHANNEL FUNCTION BRISTOL MYERS SQUIBB CO (US) 2009-08-19 EP disclosed
EP-1501467-A2 HETEROCYCLO INHIBITORS OF POTASSIUM CHANNEL FUNCTION Bristol-Myers Squibb Company (US) 2005-02-02 EP disclosed
WO-2003088908-A2 HETEROCYCLO INHIBITORS OF POTASSIUM CHANNEL FUNCTION BRISTOL-MYERS SQUIBB COMPANY (US) 2003-10-30 WO disclosed