Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 5/20 | 0.67 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.67 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.67 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.67 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.67 |
| ▸ | CYP2A6 | P11509 | 10/20 | 0.44 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | CYP2E1 | P05181 | 3/20 | 0.38 |
| ▸ | CYP2B6 | P20813 | 3/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7900617 | 0.88 | CHRM1 (0.74) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL7609678 | 0.87 | CHRM1 (0.69) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL7617382 | 0.86 | CHRM1 (0.71) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL7610514 | 0.85 | CHRM1 (0.70) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL7611120 | 0.85 | CHRM2 (0.62) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL7613377 | 0.84 | CHRM1 (0.64) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL7613448 | 0.83 | CHRM1 (0.68) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL7611966 | 0.83 | CHRM1 (0.68) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL6908445 | 0.83 | CHRM1 (0.68) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL7611380 | 0.83 | CHRM2 (0.65) | CHRM1CHRM2CHRM4CHRM5CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1355646-B1 | MUSCARINIC RECEPTOR AGONISTS | UNIV TOLEDO (US) | 2009-05-13 | — | — | EP | disclosed |
| EP-1355646-A4 | MUSCARINIC RECEPTOR AGONISTS | UNIV TOLEDO (US) | 2004-06-16 | — | — | EP | disclosed |
| EP-1355646-A1 | MUSCARINIC RECEPTOR AGONISTS | UNIVERSITY OF TOLEDO (US) | 2003-10-29 | — | — | EP | disclosed |
| WO-2002060444-A1 | MUSCARINIC RECEPTOR AGONISTS | UNIVERSITY OF TOLEDO, THE a University instrumentality of the State of Ohio (US) | 2002-08-08 | — | — | WO | disclosed |
| US-6376675-B2 | PYRIDYL-1,2,5-THIADIAZOLE DERIVATIVES | THE UNIVERSITY OF TOLEDO | 2002-04-23 | — | — | US | disclosed |
| US-20010036953-A1 | Pyridyl-1,2,5-thiadiazole derivatives | TOLEDO, THE UNIVERSITY OF | 2001-11-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010036953-A1 | Pyridyl-1,2,5-thiadiazole derivatives | CHRM3, CHRNA3, CHRNA2 | CHRM1 10/4885CHRM2 4/4885CHRM4 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.