Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24676691 | 0.80 | MAPT (0.41) | MAPTHPGDCYP3A4ALDH1A1KMT2A | |
| SCHEMBL26026737 | 0.77 | ALDH1A1 (0.47) | MAPTHPGDALDH1A1KMT2AMEN1 | |
| SCHEMBL26026735 | 0.77 | ALDH1A1 (0.43) | MAPTHPGDCYP3A4ALDH1A1KMT2A | |
| SCHEMBL6098126 | 0.76 | ALDH1A1 (0.46) | MAPTHPGDALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL20624898 | 0.76 | MAPT (0.37) | MAPTHPGDCYP3A4ALDH1A1KMT2A | |
| SCHEMBL15543574 | 0.74 | TSHR (0.51) | MAPTALDH1A1KMT2AMEN1CYP2C19 | |
| SCHEMBL26614272 | 0.73 | KMT2A (0.44) | MAPTHPGDCYP3A4ALDH1A1KMT2A | |
| SCHEMBL31066733 | 0.73 | TSHR (0.41) | MAPTCYP3A4ALDH1A1CYP2C19TP53 | |
| SCHEMBL24676789 | 0.72 | PKM (0.55) | HPGDALDH1A1KMT2AMEN1TSHR | |
| SCHEMBL21987295 | 0.71 | ALDH1A1 (0.48) | MAPTHPGDCYP3A4ALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501467-A4 | HETEROCYCLO INHIBITORS OF POTASSIUM CHANNEL FUNCTION | BRISTOL MYERS SQUIBB CO (US) | 2009-08-19 | — | — | EP | disclosed |
| EP-1501467-A2 | HETEROCYCLO INHIBITORS OF POTASSIUM CHANNEL FUNCTION | Bristol-Myers Squibb Company (US) | 2005-02-02 | — | — | EP | disclosed |
| WO-2003088908-A2 | HETEROCYCLO INHIBITORS OF POTASSIUM CHANNEL FUNCTION | BRISTOL-MYERS SQUIBB COMPANY (US) | 2003-10-30 | — | — | WO | disclosed |