Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | LPAR1 | Q92633 | 3/20 | 0.38 |
| ▸ | LPAR3 | Q9UBY5 | 3/20 | 0.38 |
| ▸ | LPAR2 | Q9HBW0 | 2/20 | 0.38 |
| ▸ | CTSA | P10619 | 2/20 | 0.37 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4029114 | 0.91 | HDAC6 (0.40) | HDAC3HDAC1HDAC2HDAC6NCOR2 | |
| SCHEMBL4035115 | 0.91 | IP6K1 (0.40) | LPAR1LPAR3LPAR2CTSAGPBAR1 | |
| SCHEMBL4035057 | 0.91 | TP53 (0.41) | LPAR1LPAR3LPAR2CTSAGPBAR1 | |
| SCHEMBL4034108 | 0.91 | LPAR1 (0.44) | HDAC3HDAC1HDAC2HDAC6NCOR2 | |
| SCHEMBL4032476 | 0.90 | LPAR1 (0.43) | LPAR1LPAR3LPAR2CTSAGPBAR1 | |
| SCHEMBL4030912 | 0.89 | HDAC3 (0.40) | HDAC3HDAC1HDAC2HDAC6NCOR2 | |
| SCHEMBL4034077 | 0.88 | HDAC3 (0.41) | HDAC3HDAC1HDAC2HDAC6NCOR2 | |
| SCHEMBL4032925 | 0.87 | LPAR1 (0.42) | LPAR1LPAR3LPAR2MEN1KMT2A | |
| SCHEMBL4034287 | 0.86 | SLC16A3 (0.37) | LPAR1LPAR3LPAR2CTSAGPBAR1 | |
| SCHEMBL4033684 | 0.86 | NPC1 (0.39) | LPAR1LPAR3LPAR2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1258484-B1 | NOVEL ISOXAZOLE AND THIAZOLE COMPOUNDS AND USE THEREOF AS DRUGS | KYOWA HAKKO KIRIN CO LTD (JP) | 2009-01-14 | — | — | EP | claimed |