Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.40 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.40 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 2/20 | 0.37 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.36 |
| ▸ | BRD2 | P25440 | 1/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | TACR3 | P29371 | 1/20 | 0.36 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4027903 | 0.89 | HTT (0.45) | LPAR1LPAR3BRD4BRD2CREBBP | |
| SCHEMBL4029114 | 0.89 | HDAC6 (0.40) | HDAC3HDAC1HDAC2HDAC6NCOR2 | |
| SCHEMBL4033561 | 0.88 | LPAR1 (0.42) | LPAR1LPAR3TRPM8MEN1KMT2A | |
| SCHEMBL4030964 | 0.88 | HDAC3 (0.39) | HDAC3HDAC1HDAC2HDAC6NCOR2 | |
| SCHEMBL4030912 | 0.87 | HDAC3 (0.40) | HDAC3HDAC1HDAC2HDAC6NCOR2 | |
| SCHEMBL4034366 | 0.83 | AKR1C3 (0.43) | LPAR1LPAR3MEN1KMT2AHTT | |
| SCHEMBL4028121 | 0.83 | LPAR1 (0.44) | HSP90AA1LPAR1LPAR3MEN1KMT2A | |
| SCHEMBL4031584 | 0.82 | LPAR1 (0.43) | LPAR1LPAR3MEN1KMT2AHTT | |
| SCHEMBL4030969 | 0.81 | LPAR1 (0.38) | HDAC6LPAR1LPAR3MEN1KMT2A | |
| SCHEMBL15437361 | 0.81 | RORC (0.38) | LPAR1LPAR3BRD4MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1258484-B1 | NOVEL ISOXAZOLE AND THIAZOLE COMPOUNDS AND USE THEREOF AS DRUGS | KYOWA HAKKO KIRIN CO LTD (JP) | 2009-01-14 | — | — | EP | claimed |