Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.38 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.36 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.36 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15437794 | 0.90 | LPAR1 (0.41) | NPC1RAB9AKMT2ALMNAMAPT | |
| SCHEMBL4034300 | 0.90 | LPAR1 (0.41) | NPC1RAB9AKMT2ALMNAMAPT | |
| SCHEMBL4034366 | 0.88 | AKR1C3 (0.43) | NPC1RAB9AALDH1A1MEN1KMT2A | |
| SCHEMBL4035057 | 0.87 | TP53 (0.41) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL4035115 | 0.87 | IP6K1 (0.40) | RAB9AALDH1A1LMNAHTTAKR1C2 | |
| SCHEMBL4034108 | 0.86 | LPAR1 (0.44) | ALDH1A1MEN1KMT2ALMNAMAPT | |
| SCHEMBL4030964 | 0.86 | HDAC3 (0.39) | ALDH1A1MEN1KMT2ALMNACYP1A2 | |
| SCHEMBL4032925 | 0.83 | LPAR1 (0.42) | RAB9AALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL4034159 | 0.81 | LPAR1 (0.44) | NPC1RAB9AALDH1A1MEN1KMT2A | |
| SCHEMBL4032395 | 0.81 | LPAR1 (0.40) | MAPTLPAR1LPAR2LPAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1258484-B1 | NOVEL ISOXAZOLE AND THIAZOLE COMPOUNDS AND USE THEREOF AS DRUGS | KYOWA HAKKO KIRIN CO LTD (JP) | 2009-01-14 | — | — | EP | claimed |