Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.42 |
| ▸ | DPP4 | P27487 | 2/20 | 0.40 |
| ▸ | ACHE | P22303 | 2/20 | 0.37 |
| ▸ | SIRT2 | Q8IXJ6 | 6/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ERN1 | O75460 | 1/20 | 0.34 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.34 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4024270 | 0.90 | MAPT (0.44) | MAPTLMNAHTTBLMSIRT1 | |
| SCHEMBL13848956 | 0.81 | LMNA (0.42) | MAPTLMNAACHESIRT2BCHE | |
| SCHEMBL8128999 | 0.81 | KDM4E (0.39) | MAPTSIRT1MEN1KMT2A | |
| SCHEMBL3565631 | 0.80 | MAPT (0.44) | MAPTLMNAHTTBLMSIRT1 | |
| SCHEMBL3568948 | 0.80 | MAPT (0.44) | MAPTLMNAHTTBLMSIRT1 | |
| SCHEMBL30003445 | 0.76 | KDM4E (0.53) | MAPTLMNAHTTSIRT1ACHE | |
| SCHEMBL29670013 | 0.76 | KDM4E (0.53) | MAPTLMNAHTTSIRT1ACHE | |
| SCHEMBL371993 | 0.76 | KDM4E (0.53) | MAPTLMNAHTTSIRT1ACHE | |
| SCHEMBL3568497 | 0.76 | MAPT (0.52) | MAPTLMNAHTTBLMSIRT1 | |
| SCHEMBL14548104 | 0.73 | MAPT (0.38) | MAPTLMNAHTTBLMSIRT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1222174-B1 | IMIDAZOL-4-YLMETHANOLS USED AS INHIBITORS OF STEROID C17-20 LYASE | TAKEDA PHARMACEUTICAL (JP) | 2009-05-27 | — | — | EP | disclosed |
| US-6649643-B1 | Antitumor, anticarcinogenic, and antimetastasis agents; benign prostatic hyperplasia, alopecia, endometriosis, uterine myoma, hirsutism, virilism, precocious puberty, mastopathy, and polycystic overay syndrome treatment | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2003-11-18 | — | — | US | disclosed |
| EP-0755527-B1 | PHOTOCHROMIC NAPHTHOPYRAN COMPOUNDS | PPG IND OHIO INC (US) | 2000-03-15 | — | — | EP | disclosed |
| US-5674432-A | USED FOR OPHTHALMIC LENSES | TRANSITIONS OPTICAL, INC. (US) | 1997-10-07 | — | — | US | disclosed |
| EP-0755527-A4 | PHOTOCHROMIC NAPHTHOPYRAN COMPOUNDS | PPG INDUSTRIES INC (US) | 1997-06-18 | — | — | EP | disclosed |
| EP-0755527-A1 | PHOTOCHROMIC NAPHTHOPYRAN COMPOUNDS | PPG INDUSTRIES, INC. (US) | 1997-01-29 | — | — | EP | disclosed |
| US-5565147-A | OPHTHALMIC LENSES | TRANSITIONS OPTICAL, INC. (US) | 1996-10-15 | — | — | US | disclosed |
| WO-1995027914-A1 | PHOTOCHROMIC NAPHTHOPYRAN COMPOUNDS | PPG INDUSTRIES, INC. (US) | 1995-10-19 | — | — | WO | disclosed |
| US-5451344-A | Opthalmic lenses or transparencies for photochromic compounds | TRANSITIONS OPTICAL, INC. (US) | 1995-09-19 | — | — | US | disclosed |