Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | SIRT2 | Q8IXJ6 | 7/20 | 0.38 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | DPP4 | P27487 | 2/20 | 0.36 |
| ▸ | ERN1 | O75460 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | AHR | P35869 | 2/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3568948 | 0.97 | MAPT (0.44) | MAPTLMNAHTTBLMSIRT2 | |
| SCHEMBL3568497 | 0.93 | MAPT (0.52) | MAPTLMNAHTTBLMSIRT2 | |
| SCHEMBL13568204 | 0.91 | MAPT (0.38) | MAPTLMNAHTTBLMSIRT2 | |
| SCHEMBL14548104 | 0.88 | MAPT (0.38) | MAPTLMNAHTTBLMSIRT2 | |
| SCHEMBL3561759 | 0.86 | SIRT2 (0.40) | MAPTLMNAHTTBLMSIRT2 | |
| SCHEMBL13568115 | 0.84 | LMNA (0.44) | MAPTLMNAHTTBLMSIRT2 | |
| SCHEMBL24399507 | 0.81 | LMNA (0.41) | MAPTLMNAHTTBLMSIRT2 | |
| SCHEMBL4031496 | 0.80 | MAPT (0.42) | MAPTLMNAHTTBLMSIRT2 | |
| SCHEMBL14870330 | 0.79 | CYP2A6 (0.44) | MAPTSIRT2SIRT1MEN1KMT2A | |
| SCHEMBL13568203 | 0.76 | SMPD1 (0.34) | NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7771801-B2 | Chiral compounds | MERCK PATENT GMBH (DE) | 2010-08-10 | — | — | US | disclosed |
| US-7771801-B2 | Chiral compounds | MERCK PATENT GMBH (DE) | 2010-08-10 | — | — | US | disclosed |
| EP-1928854-B1 | CHIRAL COMPOUNDS | MERCK PATENT GMBH (DE) | 2009-12-16 | — | — | EP | disclosed |
| US-20080281108-A1 | Chiral Compounds | MERCK PATENT GMBH (DE) | 2008-11-13 | — | — | US | disclosed |
| US-20080281108-A1 | Chiral Compounds | MERCK PATENT GMBH (DE) | 2008-11-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080281108-A1 | Chiral Compounds | LAGE3, DDT, CUTA | MAPT 2299/4885LMNA 761/4885HTT 598/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.