Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTNNB1 | P35222 | 2/20 | 0.34 |
| ▸ | WNT3A | P56704 | 2/20 | 0.34 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.33 |
| ▸ | SIRT2 | Q8IXJ6 | 7/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | BLM | P54132 | 1/20 | 0.30 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1414929 | 0.80 | SIRT2 (0.36) | SIRT2ALDH1A1MAPTHPGDMEN1 | |
| SCHEMBL4030987 | 0.79 | MEN1 (0.51) | ENPP2SIRT2MAPTMEN1KMT2A | |
| SCHEMBL4023986 | 0.78 | VNN1 (0.36) | CTNNB1WNT3AENPP2SIRT2ALDH1A1 | |
| SCHEMBL4027506 | 0.77 | ENPP2 (0.31) | ENPP2SIRT2 | |
| SCHEMBL4029004 | 0.76 | NPC1 (0.37) | CTNNB1WNT3AENPP2ALDH1A1MAPT | |
| SCHEMBL4024355 | 0.76 | SIRT2 (0.41) | SIRT2MAPTRAB9A | |
| SCHEMBL313125 | 0.76 | ACSS2 (0.43) | SIRT2 | |
| SCHEMBL5678341 | 0.76 | KDM4E (0.46) | SIRT2ALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL1414832 | 0.76 | SIRT2 (0.37) | SIRT2ALDH1A1MAPTKDM4ERAB9A | |
| SCHEMBL1414925 | 0.76 | SIRT2 (0.34) | SIRT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1222174-B1 | IMIDAZOL-4-YLMETHANOLS USED AS INHIBITORS OF STEROID C17-20 LYASE | TAKEDA PHARMACEUTICAL (JP) | 2009-05-27 | — | — | EP | disclosed |
| US-6649643-B1 | Antitumor, anticarcinogenic, and antimetastasis agents; benign prostatic hyperplasia, alopecia, endometriosis, uterine myoma, hirsutism, virilism, precocious puberty, mastopathy, and polycystic overay syndrome treatment | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2003-11-18 | — | — | US | disclosed |