Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC2 | Q92769 | 6/20 | 0.48 |
| ▸ | FASN | P49327 | 5/20 | 0.44 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.43 |
| ▸ | MGLL | Q99685 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4030 | 1.00 | HDAC2 (0.48) | HDAC2FASNNPY5RHDAC3HDAC1 | |
| SCHEMBL11953 | 0.91 | NPY5R (0.44) | HDAC2FASNNPY5RHDAC3HDAC1 | |
| SCHEMBL11908825 | 0.86 | USP30 (0.39) | HDAC2FASNHDAC3HDAC1 | |
| SCHEMBL10319 | 0.86 | LIPC (0.46) | HDAC2GAA | |
| SCHEMBL7675 | 0.84 | FASN (0.44) | HDAC2FASN | |
| SCHEMBL7673 | 0.84 | FASN (0.44) | HDAC2FASN | |
| SCHEMBL10293 | 0.84 | ALDH1A1 (0.48) | FASN | |
| SCHEMBL10298 | 0.83 | F10 (0.41) | HDAC2FASNHDAC3HDAC1 | |
| SCHEMBL6121 | 0.83 | NPY5R (0.42) | FASNNPY5RMGLLHSD11B1 | |
| SCHEMBL6123 | 0.83 | NPY5R (0.42) | FASNNPY5RMGLLHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2493310-A1 | BENZIMIDAZOLES AS FATTY ACID SYNTHASE INHIBITORS | GlaxoSmithKline LLC (US) | 2012-09-05 | — | — | EP | disclosed |
| WO-2011056635-A1 | BENZIMIDAZOLES AS FATTY ACID SYNTHASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2011-05-12 | — | — | WO | disclosed |