Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FASN | P49327 | 2/20 | 0.44 |
| ▸ | KDM1A | O60341 | 5/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.41 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.40 |
| ▸ | VNN1 | O95497 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.37 |
| ▸ | TNF | P01375 | 1/20 | 0.36 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | TDO2 | P48775 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7673 | 1.00 | FASN (0.44) | FASNKDM1AKCNH2USP30PAX8 | |
| SCHEMBL6060 | 0.92 | FASN (0.44) | FASNKDM1AKCNH2USP30PAX8 | |
| SCHEMBL6062 | 0.92 | FASN (0.44) | FASNKDM1AKCNH2USP30PAX8 | |
| SCHEMBL5915 | 0.84 | KMT2A (0.44) | FASNKDM1AKCNH2USP30PAX8 | |
| SCHEMBL5913 | 0.84 | KMT2A (0.44) | FASNKDM1AKCNH2USP30PAX8 | |
| SCHEMBL4030 | 0.84 | HDAC2 (0.48) | FASNHDAC2 | |
| SCHEMBL11908825 | 0.84 | USP30 (0.39) | FASNKDM1AUSP30HDAC2IDO1 | |
| SCHEMBL4032 | 0.84 | HDAC2 (0.48) | FASNHDAC2 | |
| SCHEMBL6635 | 0.82 | KMT2A (0.52) | FASNKDM1AKCNH2USP30VNN1 | |
| SCHEMBL6637 | 0.82 | KMT2A (0.52) | FASNKDM1AKCNH2USP30VNN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2493310-A1 | BENZIMIDAZOLES AS FATTY ACID SYNTHASE INHIBITORS | GlaxoSmithKline LLC (US) | 2012-09-05 | — | — | EP | disclosed |
| WO-2011056635-A1 | BENZIMIDAZOLES AS FATTY ACID SYNTHASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2011-05-12 | — | — | WO | disclosed |