Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OGA | O60502 | 1/20 | 0.47 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 10/20 | 0.41 |
| ▸ | LCAT | P04180 | 4/20 | 0.38 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5209950 | 0.85 | HRH3 (0.48) | OGAHRH3SLC6A9 | |
| SCHEMBL4033947 | 0.80 | CXCR3 (0.40) | OGACXCR3HRH3LCAT | |
| SCHEMBL13683688 | 0.78 | HRH3 (0.65) | OGAHRH3SLC6A9 | |
| SCHEMBL3868433 | 0.74 | HRH3 (0.72) | OGAHRH3SLC6A9 | |
| Hydrochloric Acid SCHEMBL3861682 | 0.74 | HRH3 (0.71) | OGAHRH3SLC6A9 | |
| SCHEMBL4034653 | 0.74 | HRH3 (0.44) | HRH3LCAT | |
| SCHEMBL20249325 | 0.71 | HRH3 (0.48) | OGAHRH3 | |
| SCHEMBL9920471 | 0.71 | OGA (0.42) | OGACXCR3LCATSLC6A9 | |
| SCHEMBL9923207 | 0.71 | OGA (0.42) | OGACXCR3LCATSLC6A9 | |
| SCHEMBL27728018 | 0.71 | OGA (0.50) | OGACXCR3HRH3LCATSLC6A9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7638631-B2 | Methylene dipiperidine derivatives | GLAXO GROUP LIMITED (GB) | 2009-12-29 | — | — | US | claimed |
| EP-1789410-B1 | METHYLENE DIPIPERIDINE DERIVATIVES | GLAXO GROUP LTD (GB) | 2009-06-17 | — | — | EP | claimed |
| US-20080108624-A1 | Methylene Dipiperidine Derivatives | GLAXO GROUP LIMITED (GB) | 2008-05-08 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080108624-A1 | Methylene Dipiperidine Derivatives | DRD2, DRD4, PNMT | OGA 4527/4885CXCR3 3867/4885HRH3 620/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.