Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | METAP2 | P50579 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3918988 | 0.89 | ATM (0.43) | SIGMAR1ATMRIPK1ALDH1A1KDM4E | |
| SCHEMBL3923623 | 0.88 | ATM (0.44) | SIGMAR1ATMRIPK1ALDH1A1KDM4E | |
| SCHEMBL3916075 | 0.85 | LMNA (0.44) | ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL3926307 | 0.85 | KMT2A (0.44) | ALDH1A1KDM4EMAPTCXCR3POLB | |
| SCHEMBL3920433 | 0.85 | ATM (0.40) | SIGMAR1ATMALDH1A1KDM4EPOLB | |
| SCHEMBL3916348 | 0.84 | ATM (0.37) | SIGMAR1ATMRIPK1ALDH1A1KDM4E | |
| SCHEMBL2939186 | 0.84 | ATM (0.43) | SIGMAR1ATMRIPK1ALDH1A1KDM4E | |
| SCHEMBL5151456 | 0.83 | CYP2C9 (0.44) | SIGMAR1ATMRIPK1ALDH1A1KDM4E | |
| SCHEMBL1799713 | 0.82 | RIPK1 (0.46) | SIGMAR1ATMRIPK1ALDH1A1KDM4E | |
| SCHEMBL1800386 | 0.82 | NPC1 (0.41) | SIGMAR1ATMRIPK1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1730144-B1 | SUBSTITUTED 1,4,8-TRIAZASPIRO¬4.5 DECAN-2-ONE COMPOUNDS | GRUENENTHAL GMBH (DE) | 2009-06-10 | — | — | EP | claimed |